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L-Asparginase toxicity profile at a tertiary care hematology centre in kashmir – 10 year experience.

Shakeeb Nabi, Syed Nazima, Asif Ahmed, Yasir Bashir, Sajad Geelani Javid Rasool, Nusrat Bashir, Dekyong Angmo

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Purpose: To study overall incidence of adverse effects, highlight incidence of life threatening complications, identify unusual complication if any and possible measures to prevent them.

Materials and methods: This was a ten year retrospective study where in data related to patients at presentation and data related to complications was taken from regional cancer registry and was compiled.

Conclusion:Asparaginase is aessential  component of acute leukemia  protocols . The ability to rapidly identify and manage asparaginase-associated toxicity will help ensure patients receive the maximal benefit from asparaginase therapy.

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