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A Comparative Study Following Single-Dose Versus Three-Dose Perioperative Antimicrobial Prophylaxis In Clean Elective Surgical Cases

Bikash Rayamajhi, Sunil Basukala

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Background: Appropriate antibiotic prophylaxis in surgery is directed towards the most likely pathogens encountered during the surgical procedure. The type of operative procedure is helpful in deciding the appropriate antibiotic spectrum.

Aim & objective: Evaluate and compare the outcomes following single-dose versus three-dose perioperative antimicrobial prophylaxis in clean elective surgical cases.

Methodology: 200 patients undergoing clean elective surgery were divided in two groups based on odd and even registration numbers.The studyGroup I received a single dose of injection cefotaxime (30 mg/kg/dose) half an hour prior to start of surgery.Group II received three doses of antimicrobial agent and the follow up was done till 1 month following surgery for Surgical Site Infection. Data were analyzed using Chi square test and Fischer exact test in SPSS version 20.

Results: Out of 100 patients included in the study in each group, 3 patients (3%) in single dose group and 4 patients (4%) in three dose group developed SSI within 30 days of surgery.

Discussion: Indiscriminate use of antibiotics is discouraged because it may lead to the emergence of antibiotic-resistant strains of organisms or serious hypersensitivity reactions.

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