Innovative Journal Journal of Medical Biomedical and Applied Sciences 2277:4939 10 05 Epidemiological aspects and therapeutic results of tuberculosis cases in the department of respiratory diseases, Befelatanana University Hospital 1 Harison Michel TIARAY Department of pneumonology, Tertiary hospital of Joseph Raseta Befelantanana, Antananarivo, Madagascar Kiady RAVAHATRA Department of pneumonology, Tertiary hospital of Fenoarivo, Antananarivo, Madagascar Jobeline RAJAOARIFETRA Department of pneumonology, Tertiary hospital of Tamatave, Antananarivo, Madagascar Oninala Fenitra RAKOTONDRASOA Department of pneumonology, Tertiary hospital of Joseph Raseta Befelantanana, Antananarivo, Madagascar Iantsotiana Davidson RAKOTONDRABE Department of pneumonology, Tertiary hospital of Joseph Raseta Befelantanana, Antananarivo, Madagascar Marie odette RASOAFARANIRINA Department of pneumonology, Tertiary hospital of Tamatave, Antananarivo, Madagascar Anjara Mihaja NANDIMBINIAINA Department of pneumonology, Tertiary hospital of Joseph Raseta Befelantanana, Antananarivo, Madagascar Jocelyn Rakotomizao Department of pneumonology, Tertiary hospital of Joseph Raseta Befelantanana, Antananarivo, Madagascar Rakotoson Joelson Lovaniaina Department of pneumonology, Tertiary hospital of Joseph Raseta Befelantanana, Antananarivo, Madagascar ANDRIANASOLO Radonirina Lazasoa Department of Infectious desease, Tertiary hospital of Joseph Raseta Befelantanana, Antananarivo, Madagascar RAHARIMANANA Rondro Nirina Department of pneumonology, Tertiary hospital of Fenoarivo, Antananarivo, Madagascar Journal Article https://doi.org/10.15520/ijmhs.v10i03.285 Abstract Introduction: One of the ways to assess the quality of the treatment of tuberculosis is to analyze the treatment of outcomes the patients followed up. Our objective is to describe the epidemiological aspects and the therapeutic results of tuberculosis patients seen at the Joseph Raseta Befelatanana University Hospital Center. Methods: This is a retrospective and descriptive cohort study from January 1st, 2014 to December 31, 2017. Data were collected from the tuberculosis registry. Results: We included 759 cases, the average age were 36.48 years. There was male predominance a sex ratio of 1.62. The pulmonary forms tuberculosis predominated (62.50%). Pleural (51.58%) and lymph node (16.49%) lesions were the most frequent extra pulmonary forms. The prevalence of TB-HIV coinfection was 5.80%. The treatment success rate for all forms was 84.46%, it was 90.50% for the smear positive pulmonary tuberculosis. Age, type of tuberculosis and HIV status influenced treatment outcomes (p <0.05). Conclusion: The data on the therapeutic outcome of our study meets the objective of the WHO. Other multicenter studies are necessary to answer certain questions that were not clarified during our study in relation to the other factors influencing therapeutic outcomes in Madagascar. Oms, Rapport, de l'OMS sur la lutte contre la tuberculose, 2017, https://www.theunion.org.../dapres-le-rapport-2017-de-l’OMS-sur-la-lutte-contre-latuberculose Ali, M K, «Factors associated with tuberculosis treatment outcomes among tuberculosis patients attending tuberculosis treatment centres in 2016, PAMJ, 2017, 28, 1, 14 Holmes, C B, A review of sex differences in the epidemiology of tuberculosis, Int J Tuberc Lung Dis, 1998, 2, 1, 9 Gonzalez, O Y, Extra-pulmonary manifestations in a large metropolitan area with low incidence of tuberculosis, Int J Tuberc Lung Dis, 2003, 12, 1178, 85 Woessner, J, Epidémiologie de la tuberculose à Mayotte, Bull Soc Pathol Exot, 2008, 101, 1, 7 Shiying, L, Diagnostic accuracy of Xpert MTB/RIF for tuberculosis detection in different regions with different endemic burden : a systematic review and meta-analysis, PlosONE, 2017, 7, 1, 13 Islam, S., Hirayama, T., Islam, A., Ishikawa, N., Afsana, K., Treatment referral system for tuberculosis patients in Dhaka, Bangladesh, Public Health Action, 2015, 5, 4, 236, 240, 2220-8372, 2220-8372, 10.5588/pha.15.0052, International Union Against Tuberculosis and Lung Disease, https://dx.doi.org/10.5588/pha.15.0052 Datiko, Daniel G, Yassin, Mohammed A, Chekol, Luelseged T, Kabeto, Lopisso E, Lindtjørn, Bernt, The rate of TB-HIV co-infection depends on the prevalence of HIV infection in a community, BMC Public Health, 2008, 8, 1, 1, 10, 1471-2458, 10.1186/1471-2458-8-266, Springer Science and Business Media LLC, https://dx.doi.org/10.1186/1471-2458-8-266 Mangtani, Punam, Abubakar, Ibrahim, Ariti, Cono, Beynon, Rebecca, Pimpin, Laura, Fine, Paul E. M., Rodrigues, Laura C., Smith, Peter G., Lipman, Marc, Whiting, Penny F., Sterne, Jonathan A., Protection by BCG Vaccine Against Tuberculosis: A Systematic Review of Randomized Controlled Trials, Clinical Infectious Diseases, 2014, 58, 4, 470, 480, 1058-4838, 1537-6591, 10.1093/cid/cit790, Oxford University Press (OUP), https://dx.doi.org/10.1093/cid/cit790 Atif, M, Treatment outcome of new smear positive pulmonary tuberculosis patients in Penang, Malaysia, BMC Infect Dis, 2014, 14, 1, 1, 8 Antoine, D, Les issues de traitement des cas de tuberculose déclarés en France en, Bull Epidémiol Hebd, 2008, 32, 1, 8 Ministère de la santé et du planning familial. Manuel du programme National Tuberculose à Madagascar, 4ème édition, 2011, 11, 85 Wang, J, Gender difference in knowledge of tuberculosis and associated health-care seeking behaviors : a cross-sectional study in a rural area of China, BMC Public Health, 2008, 8, 1, 7 Babatunde, O, Factors affecting treatment outcomes of tuberculosis in a tertiary health center in southwestern Nigeria, Int Rev Soc Sci Hum, 2013, 4, 209, 220 Rakotonirina, E J, Facteurs contextuels de l’efficacité du contrôle de la tuberculose à Madagascar : étude de validité au niveau national, Med Sante Trop, 2016, 26, 64, 70 Sreeramareddy, Chandrashekhar T, Panduru, Kishore V, Verma, Sharat C, Joshi, Hari S, Bates, Michael N, Comparison of pulmonary and extrapulmonary tuberculosis in Nepal- a hospital-based retrospective study, BMC Infectious Diseases, 2008, 8, 1, 1, 6, 1471-2334, 10.1186/1471-2334-8-8, Springer Science and Business Media LLC, https://dx.doi.org/10.1186/1471-2334-8-8 Lin, J N, Risk factors for extrapulmonary tuberculosis compare to pulmonary tuberculosis, Int J Tuberc Lung Dis, 2009, 5, 620, 625 Arega, Balew, Tilahun, Kelemu, Minda, Abraham, Agunie, Asnake, Mengistu, Getachew, Prevalence rate of undiagnosed tuberculosis in the community in Ethiopia from 2001 to 2014: systematic review and meta-analysis, Archives of Public Health, 2019, 77, 1, 7, 2049-3258, Springer Science and Business Media LLC, 10.1186/s13690-019-0360-2, https://dx.doi.org/10.1186/s13690-019-0360-2 WHO. Treatment of tuberculosis: guidelines 4th, www.who.int/tb/publications/global_report/gtbr2017