Innovative Journal Journal of Medical Biomedical and Applied Sciences 2277:4939 10 11 Can an oral supplement with Sambucus nigra, Zinc, Tyndallized Lactobacillus acidophilus (HA122), Arabinogalactans, vitamin D, vitamin E and vitamin C, improve post-surgery quality of recovery? Survey among adult and children to identify potential benefit. 1 Alessandro Maselli Del Giudice Otolaryngology department - Monsignor Raffaele Dimiccoli Hospital, Barletta, Italy Francesco Barbara Otolaryngology department - Monsignor Raffaele Dimiccoli Hospital, Barletta, Italy Francesco Cariti Otolaryngology department - Monsignor Raffaele Dimiccoli Hospital, Barletta, Italy Salvatore Dadduzio Otolaryngology department - Monsignor Raffaele Dimiccoli Hospital, Barletta, Italy Valentina De Robertis Otolaryngology department - Monsignor Raffaele Dimiccoli Hospital, Barletta, Italy Silvana Ciccarone Otolaryngology department - Monsignor Raffaele Dimiccoli Hospital, Barletta, Italy Michele Barbara Otolaryngology department - Monsignor Raffaele Dimiccoli Hospital, Barletta, Italy Journal Article https://doi.org/10.15520/ijmhs.v10i11.3138 Abstract Abstract: Oral supplements have known abilities to stimulate immune-answer. In addition, some molecules, such as those extracted from Sambucus nigra, have a strong antibacterial and antiviral capacity. For these reasons, oral supplementation is used to improve the immune system. In this study we aim to investigate how an oral supplement with multi-element can support the recovery of patients who underwent surgery. To this aim we separately analyzed a sample of 130 patients under 17 years and 130 adults. All patients were treated by antibiotic therapy and assigned to group 1, 2, 3 or control (subgroups) based on the treatment with oral supplement performed. Each group followed a specific treatment by nutraceuticals (Difensil Immuno and/or Vitamin D). The health condition of the patients was investigated by looking at their blood test and using a validated questionnaire. All patients who underwent oral supplementation showed a higher percentage of positive answers to the questionnaire than control groups. Based on the results, our study shows that oral supplementation with selected and specific elements like Sambucus nigra, Zinc, Tyndallized Lactobacillus acidophilus (HA122), Arabinogalactans, vitamin D, vitamin E and vitamin C, can be a valid support to immune system, after surgery both in adults and children.