Innovative Journal Innovative Journal of Medical and Health Science 2589-9341 11 05 2021 5 5 PATTERN OF LEFT VENTRICULAR ABNORMALITIES IN PEOPLE WITH PREDIABETES 1 Mohd Abass Bhat Senior Resident Department of Medicine, Goverrnment Medical College, J & K, Srinagar, India Nazir A Pala Assistant Professor Department of Medicine, Goverrnment Medical College, J & K, Srinagar, India Manzoor Syed Anderabi Associate Professor Department of Medicine, Goverrnment Medical College, J & K, Srinagar, India Shahnawaz Hassan Senior Resident Department of Medicine, Goverrnment Medical College, J & K, Srinagar, India Journal Article 101550.ijmhs.123 Abstract Purpose of study: Left ventricular dysfunction in people with diabetes mellitus has been demonstrated by various studies in past. However, there is little and conflicting data with regard to Left Ventricular abnormalities in people with Pre-diabetes. In view of Scarcity of data, we designed a study to investigate the early abnormalities in left ventricular function in normotensive people with prediabetes compared to healthy controls, using Doppler Echocardiography Methods: Prospective hospital based case-control study, conducted at a tertiary care hospital in north India. 100 people with prediabetes without known cardiovascular disease, with equal number of matched controls were enrolled in the study. A detailed medical history, clinical examination, biochemical profile and echocardiographic studies were performed in all study subjects. Results: Early diastolic wave (E;0.693±0.092m/s), Early diastolic wave (E)/late diastolic wave (A) ratio (E/A;0.887±0.095), left ventricular end systolic diameter (LVESD; 24.78±1.640mm) were significantly lower in people with prediabetes, whereas isovolumetric relaxation time (IVRT;87.45±8.148ms), sphericity index (0.595±0.028) and left atrial diameter (35.50±1.693mm) were significantly higher in people with pre-diabetes compared to matched controls. However, no correlation was observed with regard to anthropometric variables (body-mass index (BMI), waist circumference) and lipid profile Conclusion: Prediabetes is associated with subclinical left Ventricular systolic and diastolic abnormalities as evaluated on conventional and pulse-wave echocardiography. Cheng, Y J, Gregg, E W, Geiss, L S, Imperatore, G, Williams, D E, Zhangx, American Diabetes Association. 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