Innovative Journal Innovative Journal of Medical and Health Science 2589-9341 11 05 2021 5 19 A CLINICAL EVALUATION OF PROPOFOL IN SHORT SURGICAL PROCEDURES AND COMPARISON WITH THIOPENTONE SODIUM AS INDUCTION AGENT IN IMMUNOCOMPROMISED HIV PATIENTS 1 Lalit Kumar Garg MBBS, MD (Anaesthesiology), Assistant Professor, Government Medical College, Rajindra Hospital, Patiala, India Anjana MBBS, MS (General Surgery), Assistant Professor, Government Medical College, Rajindra Hospital, Patiala, India Deepak Berry MBBS, MD (Anaesthesiology), Assistant Professor, Government Medical College, Rajindra Hospital, Patiala, India Tanveer Singh Kundra MBBS, DA, DNB (Anaesthesiology), DM (Cardiac Anaesthesia), Assistant Professor, Government Medical College, Rajindra Hospital, Patiala, India Journal Article https://doi.org/10.15520/ijmhs.v11i05.3298 Abstract BACKGROUND:Numerous attempts have been made in the past for the selection of an ideal intravenous anaesthetic agent for outpatient short surgical procedures in immunocompromised patients. The present study compared the effect of two drugs namely propofol and thiopentone sodium as an induction agent in short surgical procedures in immunocompromised HIV patients. Materials and Methods: This was a randomized study evaluating two drugs- propofol and thiopentone sodium in short surgical procedures. It was carried out on 100 immunocompromised HIV patients in age group of 18-45 yrs of ASA grade 1/2 undergoing short surgical procedures . These patients were randomly divided into 2 groups 1 and 2 which were further subdivided into 1a and 1b , 2a and 2b respectively, each consisiting of 25 pts. Group 1a and 2 a were given inj pentazocine 30mg and inj promethazine 25mg Group 1b and 2b were administered 2 ml of saline . Group 1a and 1b received inj propofol 1%i/v dose 2.5mg/kg wt and group 2a and 2b were given inj thiopentone 2.5% i/v at dose of 5mg/kg wt. RESULT: Propofol showed a greater decrease in diastolic and systolic BP at induction, respiratory rate with more incidence of apnea. CONCLUSION: Propofol produces rapid, pleasant and safe anaesthesia, with smooth recovery while thiopentone is associated with poor psychomotor recovery in immunocompromised HIV patients. Joint, Who, United Nations programme on HIV/AIDS-2006 report on the global epidemic, www.unaids.org Hare, Bradley, , OliverBacon, , Paul Vol berding, Clinical Overview of HIV Disease Laurence Peiperl, HIV knowledge base. chapter, 2006, Susa Coffey Schweitzer, C, Keller, F, Schmitt, M.P, Jaeck, D, Adloff, M, Schmitt, C, Royer, C, Kirn, A, Aubertin, A.M, Morphine stimulates HIV replication in primary cultures of human Kupffer cells, Research in Virology, 1991, 142, 2-3, 189, 195, 0923-2516, 10.1016/0923-2516(91)90056-9, Elsevier BV, https://dx.doi.org/10.1016/0923-2516(91)90056-9 Parthasarathy, S, Ravishankar, M, Hiv, Indian J Anaesth, 2007, 51, 91, 91 SQUINTO, STEPHEN P., MONDAL, DEBASIS, BLOCK, ADRIENNE L., PRAKASH, OM, Morphine-Induced Transactivation of HIV-1 LTR in Human Neuroblastoma Cells, AIDS Research and Human Retroviruses, 1990, 6, 10, 1163, 1168, 0889-2229, 1931-8405, 10.1089/aid.1990.6.1163, Mary Ann Liebert Inc, https://dx.doi.org/10.1089/aid.1990.6.1163 Continuum of care for HIV /AIDS - Hand book for health care providers, The Tamilnadu AIDS control society, 2005