Formulation of ciprofloxacin hydrochloride loaded biodegradable nanoparticles: Optimization of the formulation variables.
The aim of this work was to formulate nanoparticles with longer sustainment since it can play an important role in treatment of chronic osteomyelitis. A factorial design 23 was used to optimize the formulation variables of ciprofloxacin hydrochloride (CP) loaded biodegradable nanoparticles (NPS). The effect of three independent variables, namely; the polymer type (Poly D, L-lactide-co-glycolide 50/50& Poly (D, L-lactide), the polymer molecular weight(M.Wt) and the drug to polymer ratio on the particle size, encapsulation efficiency (EE%), zeta potential and the time required for 90% of ciprofloxacin to be released (t90%) was investigated . The selected drug loaded nanoparticles was subjected to further investigations including; Scanning electron microscope (SEM), DSC, x-ray powder diffractometry and FTIR spectroscopy. Moreover the antimicrobial effectiveness of the selected formula was investigated.
The results revealed that The mean particle size e ranged from 180-355 nm while the EE% ranged from 52-70%. The selected formula retained its antimicrobial activity throughout the preparation process.
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