Preparation and in-vitro Evaluation of Poly--Caprolactone Nanoparticles Containing Atorvastation Calcium

Authors

  • Iman Saad Ahmed Cairo University; University of Sharjah
  • Rania El Hosary
  • Samia Shalaby
  • Samia Nour

Abstract

Preparation and evaluation of poly-e-caprolactone nanoparticles containing atorvastatin calcium (AC), a drug with poor solubility and poor bioavailability, is presented. The drug loaded nanoparticles were prepared by solvent displacement method using different experimental conditions.  The influence of different formulation variables, such as type and concentration of stabilizers in the aqueous phase, concentration of polymer and surfactant in the organic phase, addition of an anti-oxidant, pH of the aqueous phase and others, on particle size, drug entrapment efficiency, in-vitro drug release along with other physico-chemical properties of the nanoparticles was investigated using several full factorial designs. The optimized AC nanoparticles showed an average particle size of less than 200 nm, a drug loading capacity of more than 70% and released the drug in a controlled fashion over 24 hour. Transmission electron microscope (TEM) revealed that the prepared AC nanoparticles were nearly spherical. Short-term stability results of selected formulae were satisfactory.

 

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Published

2014-02-23

How to Cite

Ahmed, I. S., El Hosary, R., Shalaby, S., & Nour, S. (2014). Preparation and in-vitro Evaluation of Poly--Caprolactone Nanoparticles Containing Atorvastation Calcium. Journal of Pharmaceutical Research and Opinion, 4(1). Retrieved from http://innovativejournal.in/index.php/jpro/article/view/634

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Vol. 4 No. 1 (2014): JOURNAL OF PHARMACEUTICAL RESEARCH AND OPINION

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Articles

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“I ……………………………………….certify that I have participated sufficiently in the conception and design of this work and the analysis of the data (wherever applicable), as well as the writing of the manuscript, to take public responsibility for it. I believe the manuscript represents valid work. I have reviewed the final version of the manuscript and approve it for publication. Neither has the manuscript nor one with substantially similar content under my authorship been published nor is being considered for publication elsewhere, except as described in an attachment. Furthermore I attest that I shall produce the data upon which the manuscript is based for examination by the editors or their assignees, if requested.”