SELF EMULSIFYING DRUG DELIVERY SYSTEM

Authors

  • Vishesh Kumar Pal*

Abstract

Oral route has always been preferred route for formulators and has dominated over other routes of administrations. The major problem in oral drug formulations is low and erratic bioavailability, which mainly results from poor aqueous solubility. Approximately 40% of new chemical entities exhibit poor aqueous solubility and present a major challenge to modern drug delivery system, because of their low bioavailability.  The aim of this study was to formulate a SEDDS containing a lipophilic drug, loratadine, and to explore the potential of carriers for such system. Formulation development and screening was done based on results obtained from phase diagrams and characteristics of resultant microemulsions. The optimized formulation for in vitro dissolution and pharmacodynamic studies was composed of Labrafac CM10 (31.5%), Tween 80 (47.3%), and polyethylene glycol 400 (12.7%).Self micro emulsifying drug delivery systems are isotropic mixtures of oil, surfactant, co-surfactant and drug with a unique ability to form fine oil in Water microemulsion upon mild agitation following dilution with aqueous phase. Among various approach selfemulsifying drug delivery system has gained more attention due to enhanced oral bio-availability enabling reduction in dose, more consistent temporal profiles of drug absorption, The particle sizes of formulations were influenced by type of oil, in the manner that liquid paraffin induced lower particle size in the range of 0.28- 1.8 micron.

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Published

2014-02-23

How to Cite

Pal*, V. K. (2014). SELF EMULSIFYING DRUG DELIVERY SYSTEM. Journal of Pharmaceutical Research and Opinion, 1(3). Retrieved from http://innovativejournal.in/index.php/jpro/article/view/655

Issue

Vol. 1 No. 3 (2011): JOURNAL OF PHARMACEUTICAL RESEARCH AND OPINION

Section

Articles

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“I ……………………………………….certify that I have participated sufficiently in the conception and design of this work and the analysis of the data (wherever applicable), as well as the writing of the manuscript, to take public responsibility for it. I believe the manuscript represents valid work. I have reviewed the final version of the manuscript and approve it for publication. Neither has the manuscript nor one with substantially similar content under my authorship been published nor is being considered for publication elsewhere, except as described in an attachment. Furthermore I attest that I shall produce the data upon which the manuscript is based for examination by the editors or their assignees, if requested.”