HEPATOPROTECTIVE EFFECTS OF CYATHULA PROSTRATA LINN. IN PARACETAMOL INDUCED LIVER INJURY IN RATS

Authors

  • Ramadoss S*

Abstract

Herbal medicines derived from plant extracts are being increasingly utilized to treat a wide variety of clinical disease. More attention has been paid to the protective effects of natural antioxidants against drug-induced toxicities especially whenever free radical generation is involved. The ethanolic extract of Cyathula prostrata .L. (Amaranthaceae) whole plants were investigated for its hepatoprotective effect on paracetamol (2g/kg/b.wt/p.o) induced acute liver damage in Wistar albino rats. Hepatoprotection activity was measured by diagnostic marker enzymes such as AST, ALT, ALP, bilirubin, albumin and total protein. The ethanolic extract of Cyathula prostrata (CPE) at the dose of (100 & 200 mg/kg/p.o) produced significant hepatoprotective effect by decreasing the activity of serum enzymes, bilirubin and proteins. The effects of ethanolic extract of Cyathula prostrata were comparable to that of standard drug Silymarin. These results suggest that Cyathula prostrata ethanolic extract exhibits a very significant hepatoprotective effect in albino (Wistar) male rats.

Downloads

Published

2014-02-23

How to Cite

S*, R. (2014). HEPATOPROTECTIVE EFFECTS OF CYATHULA PROSTRATA LINN. IN PARACETAMOL INDUCED LIVER INJURY IN RATS. Journal of Pharmaceutical Research and Opinion, 1(7). Retrieved from http://innovativejournal.in/index.php/jpro/article/view/686

Issue

Vol. 1 No. 7 (2011): JOURNAL OF PHARMACEUTICAL RESEARCH AND OPINION

Section

Articles

License

“I ……………………………………….certify that I have participated sufficiently in the conception and design of this work and the analysis of the data (wherever applicable), as well as the writing of the manuscript, to take public responsibility for it. I believe the manuscript represents valid work. I have reviewed the final version of the manuscript and approve it for publication. Neither has the manuscript nor one with substantially similar content under my authorship been published nor is being considered for publication elsewhere, except as described in an attachment. Furthermore I attest that I shall produce the data upon which the manuscript is based for examination by the editors or their assignees, if requested.”