DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATON OF SOME NOVEL SUBSTITUTED THIENOPYRIMIDINE DERIVATIVES

Authors

  • Sonvane Sameep, Manish Srivastav, S.M Shantakumar, M.D Salahuddin*

Abstract

Cyclization of 2-amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3- carboxamide (I) yielded 3,5,6,7-tertrahydro-4H-cyclopenta thieno[2,3-d]pyrimidine-4 (3H)-one (II). The compound (II) on reaction with POCl3 give 4-chloro-3,5,6,7-tetrahydro-4H-Cyclopenta thieno[2,3-d]pyrimidine (III). Reaction of (III) with 4-amino acetophenone give 1-[4-(3,5,6,7-tetrahydro-4H-cyclopenta-thieno[2,3-d]pyrimidine-ylamino)phenyl]ethanone (IV). Reaction of (IV) with different substituted aldehyde yielded V

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Published

2014-02-23

How to Cite

M.D Salahuddin*, S. S. M. S. S. S. (2014). DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATON OF SOME NOVEL SUBSTITUTED THIENOPYRIMIDINE DERIVATIVES. Journal of Pharmaceutical Research and Opinion, 2(3). Retrieved from http://innovativejournal.in/index.php/jpro/article/view/697

Issue

Vol. 2 No. 3 (2012): JOURNAL OF PHARMACEUTICAL RESEARCH AND OPINION

Section

Articles

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