SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL EVALUATION OF PALMITIC ACID DERIVATIVES OF SALICYLIC ACID AND ANTHRANILIC ACID

Authors

  • Asma Saqib, Chandrakant. S. Karigar, Mohammed Afzal Pasha, Metticule S, Rao Harish

Abstract

The use of high dose of NSAID is accompanied by a number of side effects in disease conditions such as jaundice, loss of consciousness, liver damage and death. Non-steroidal anti-inflammatory drugs (NSAID) like aspirin, paracetamol and diclofenac are known for their widely valued pharmacological properties; however, they are toxic to the bio systems. One can overcome this limitation by decreasing the solubility of NSAID in aqueous phase. In the present study, salicylic acid and anthranilic acid have been modified as lipids PSA and N-PAA by a simple esterification / amidation reaction of the respective acid with palmitoyl chloride. On screening for the pharmacological activity, PSA has been found to exhibit potent and persistent analgesic and anti-inflammatory effects, while N-PAA, demonstrated novel analgesic and antipyretic effects.

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Published

2014-02-23

How to Cite

Metticule S, Rao Harish, A. S. C. S. K. M. A. P. (2014). SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL EVALUATION OF PALMITIC ACID DERIVATIVES OF SALICYLIC ACID AND ANTHRANILIC ACID. Journal of Pharmaceutical Research and Opinion, 2(4). Retrieved from http://innovativejournal.in/index.php/jpro/article/view/699

Issue

Vol. 2 No. 4 (2012): JOURNAL OF PHARMACEUTICAL RESEARCH AND OPINION

Section

Articles

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