A validated RP-HPLC method for simultaneous determination of Metformin HCl, Pioglitazone HCl and Glimepiride in pharmaceutical formulation
Abstract
In the present scenario, most commonly attacking disease is diabetes. Recent studies indicate that prevalence of type-2 diabetes is rapidly increasing in the society due to life style changes. Type-2 diabetes is a progressive disorder with reduced insulin level, increased blood glucose level with a consistent and steady increase in glycosylated hemoglobin (HbA1C) overtime associated with enhanced risk of micro- and macrovascular complications and a substantial reduction in life expectancy. Pathophysiologic abnormalities associated with type-2 diabetes are: (i) impaired insulin secretion, (ii) excessive hepatic glucose output, and (iii) insulin resistance in skeletal muscles, liver and adipose tissue. These defects have been treated by use of oral insulin secretagogues (sulphonyl ureas/glinides) or insulin, biguanides, and thiazolidinediones, respectively.
References
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2. Dorkhan M and Frid A, 2007 A review of pioglitazone HCL and glimepiride in the treatment of type 2 diabetes, Vascular Health and Risk Management, vol. 3, no. 5, pp. 721–731.
3. Ramachandran A, Snehalatha C, Salini J,Vijay V, 2004 Use of glimepiride and insulin sensitizers in the treatment of type 2 diabetes—a study in Indians,†Journal of Association of Physicians of India, vol. 52, pp. 459–463.
4. Adukondalu D, Malathy P.S., Rao J.V, and Rao Y.M, 2011 Development and validation of HPLC method for detection of pioglitazone hydrochloride in dosage forms,†International Journal of Pharmacy and Biological Sciences, vol. 1, no. 4, pp. 474–478.
5. Hobard, H. W.; Hyme, L. M. Jr.; John, A. D.; Frank, A. S. Jr. 2007. Introduction Instrumental Methods of Analysis, 7th ed.; CBS Publishers and distributors: New Delhi; pp 2-3.
6. Kasture, A. V.; Mahadik, K. R.; Wadodkar, S. G.; More, H. N. 2004. Instrumental Pharmaceutical Analysis – Instrumental Methods, 9th ed.; Part-II; 6-10.
7. Skoog, D. A.; Holler, F. J.; Nieman, T. A. 2004. Principles of Instrumental Analysis, 5th ed.; Thomas Books: Cole, pp 724-725.
8. Synder, L. R.; Kirkland, J. J.; Dolan, J. W. 2010. Introduction to Modern Liquid Chromatography, 3rd ed.; A John Wiley & Sons, Inc. Publication, , 2-254.
9. Kazakevich, Y.; Lobrutto, R. 2007. HPLC for Pharmaceutical Scientist. A John Wiley & Sons: Inc. Publication, 1-25.
10. Sethi, P. D.; Sethi, R. 2007. High Performance Liquid Chromatography: Quantitative Analysis of Pharmaceutical Dosage Forms, 1st ed.; Vol. 1.; 1-200.
11. International Conference on Harmonization (ICH) of Technical Requirements for the registration of Pharmaceuticals for Human Use. Validation of analytical procedures: Methodology. ICH-Q2B Step-4. USA, Nov-1996, 1-8.
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13. British Pharmacopoeia, 2007 Vol. I, H.M. Stationary Office, London, 638.
14. Indian Pharmacopoeia, 2007, Published by Ministry of Health and Family Welfare, Government of India, Volume I & II.
15. www. google.com/ Wikipedia/ metformin hydrochloride.
16. www. google.com/ Wikipedia/ pioglitazone hydrochloride.
17. www. google.com/ Wikipedia/ glimiperide
18. http://www.drugbank.ca/drugs/DB00331 (cited on 4th nov 2009).
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Published
2014-07-30
How to Cite
O.P.Mahatma, Megha Joshi, A. T. (2014). A validated RP-HPLC method for simultaneous determination of Metformin HCl, Pioglitazone HCl and Glimepiride in pharmaceutical formulation. Journal of Pharmaceutical Research and Opinion, 3(11). Retrieved from http://innovativejournal.in/index.php/jpro/article/view/815
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