http://innovativejournal.in/index.php/jpro <!-- [if gte mso 9]><xml> <o:OfficeDocumentSettings> <o:RelyOnVML></o:RelyOnVML> <o:AllowPNG></o:AllowPNG> </o:OfficeDocumentSettings> </xml><![endif]--> <p class="MsoListParagraph" style="mso-add-space: auto; text-align: justify; text-indent: -.25in; line-height: normal; mso-list: l0 level1 lfo1; vertical-align: top; margin: 0in 0in .0001pt 31.5pt;"><strong style="mso-bidi-font-weight: normal;"><em style="mso-bidi-font-style: normal;"><span style="font-size: 16.0pt; font-family: 'Century','serif'; mso-fareast-font-family: 'Times New Roman'; mso-bidi-font-family: 'Times New Roman'; color: #365f91; mso-themecolor: accent1; mso-themeshade: 191;" lang="EN-US">&nbsp;</span></em></strong></p> <!-- [if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> <w:Zoom>0</w:Zoom> <w:TrackMoves></w:TrackMoves> <w:TrackFormatting></w:TrackFormatting> <w:PunctuationKerning></w:PunctuationKerning> <w:ValidateAgainstSchemas></w:ValidateAgainstSchemas> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <w:DoNotPromoteQF></w:DoNotPromoteQF> <w:LidThemeOther>EN-IN</w:LidThemeOther> <w:LidThemeAsian>X-NONE</w:LidThemeAsian> <w:LidThemeComplexScript>X-NONE</w:LidThemeComplexScript> <w:Compatibility> <w:BreakWrappedTables></w:BreakWrappedTables> <w:SnapToGridInCell></w:SnapToGridInCell> <w:WrapTextWithPunct></w:WrapTextWithPunct> <w:UseAsianBreakRules></w:UseAsianBreakRules> <w:DontGrowAutofit></w:DontGrowAutofit> <w:SplitPgBreakAndParaMark></w:SplitPgBreakAndParaMark> <w:DontVertAlignCellWithSp></w:DontVertAlignCellWithSp> <w:DontBreakConstrainedForcedTables></w:DontBreakConstrainedForcedTables> <w:DontVertAlignInTxbx></w:DontVertAlignInTxbx> <w:Word11KerningPairs></w:Word11KerningPairs> <w:CachedColBalance></w:CachedColBalance> </w:Compatibility> <m:mathPr> <m:mathFont m:val="Cambria Math"></m:mathFont> <m:brkBin m:val="before"></m:brkBin> <m:brkBinSub m:val="&#45;-"></m:brkBinSub> <m:smallFrac m:val="off"></m:smallFrac> <m:dispDef></m:dispDef> <m:lMargin m:val="0"></m:lMargin> <m:rMargin m:val="0"></m:rMargin> <m:defJc m:val="centerGroup"></m:defJc> <m:wrapIndent m:val="1440"></m:wrapIndent> <m:intLim m:val="subSup"></m:intLim> <m:naryLim m:val="undOvr"></m:naryLim> </m:mathPr></w:WordDocument> </xml><![endif]--><!-- [if gte mso 9]><xml> <w:LatentStyles DefLockedState="false" DefUnhideWhenUsed="true" DefSemiHidden="true" DefQFormat="false" DefPriority="99" LatentStyleCount="267"> <w:LsdException Locked="false" Priority="0" SemiHidden="false" UnhideWhenUsed="false" QFormat="true" Name="Normal"></w:LsdException> <w:LsdException Locked="false" Priority="9" SemiHidden="false" UnhideWhenUsed="false" QFormat="true" Name="heading 1"></w:LsdException> <w:LsdException Locked="false" Priority="9" QFormat="true" Name="heading 2"></w:LsdException> <w:LsdException Locked="false" Priority="9" QFormat="true" Name="heading 3"></w:LsdException> <w:LsdException Locked="false" Priority="9" QFormat="true" Name="heading 4"></w:LsdException> <w:LsdException Locked="false" Priority="9" QFormat="true" Name="heading 5"></w:LsdException> <w:LsdException Locked="false" Priority="9" QFormat="true" Name="heading 6"></w:LsdException> <w:LsdException Locked="false" Priority="9" QFormat="true" Name="heading 7"></w:LsdException> <w:LsdException Locked="false" Priority="9" QFormat="true" Name="heading 8"></w:LsdException> <w:LsdException Locked="false" Priority="9" QFormat="true" Name="heading 9"></w:LsdException> <w:LsdException Locked="false" Priority="39" Name="toc 1"></w:LsdException> <w:LsdException Locked="false" Priority="39" Name="toc 2"></w:LsdException> <w:LsdException Locked="false" Priority="39" Name="toc 3"></w:LsdException> <w:LsdException Locked="false" Priority="39" Name="toc 4"></w:LsdException> <w:LsdException Locked="false" Priority="39" Name="toc 5"></w:LsdException> <w:LsdException Locked="false" Priority="39" Name="toc 6"></w:LsdException> <w:LsdException Locked="false" Priority="39" Name="toc 7"></w:LsdException> <w:LsdException Locked="false" Priority="39" Name="toc 8"></w:LsdException> <w:LsdException Locked="false" Priority="39" Name="toc 9"></w:LsdException> <w:LsdException Locked="false" Priority="35" QFormat="true" Name="caption"></w:LsdException> <w:LsdException Locked="false" Priority="10" SemiHidden="false" UnhideWhenUsed="false" QFormat="true" Name="Title"></w:LsdException> <w:LsdException Locked="false" Priority="1" Name="Default Paragraph Font"></w:LsdException> <w:LsdException Locked="false" Priority="11" SemiHidden="false" UnhideWhenUsed="false" QFormat="true" Name="Subtitle"></w:LsdException> <w:LsdException Locked="false" Priority="22" SemiHidden="false" UnhideWhenUsed="false" QFormat="true" Name="Strong"></w:LsdException> <w:LsdException Locked="false" Priority="20" SemiHidden="false" UnhideWhenUsed="false" QFormat="true" Name="Emphasis"></w:LsdException> <w:LsdException Locked="false" Priority="59" SemiHidden="false" UnhideWhenUsed="false" Name="Table Grid"></w:LsdException> <w:LsdException Locked="false" UnhideWhenUsed="false" Name="Placeholder Text"></w:LsdException> <w:LsdException Locked="false" Priority="1" SemiHidden="false" UnhideWhenUsed="false" QFormat="true" Name="No Spacing"></w:LsdException> <w:LsdException Locked="false" Priority="60" SemiHidden="false" UnhideWhenUsed="false" Name="Light Shading"></w:LsdException> <w:LsdException Locked="false" Priority="61" SemiHidden="false" UnhideWhenUsed="false" Name="Light List"></w:LsdException> <w:LsdException Locked="false" Priority="62" SemiHidden="false" UnhideWhenUsed="false" Name="Light Grid"></w:LsdException> <w:LsdException Locked="false" Priority="63" SemiHidden="false" UnhideWhenUsed="false" Name="Medium Shading 1"></w:LsdException> <w:LsdException Locked="false" Priority="64" SemiHidden="false" UnhideWhenUsed="false" Name="Medium Shading 2"></w:LsdException> <w:LsdException Locked="false" Priority="65" SemiHidden="false" UnhideWhenUsed="false" Name="Medium List 1"></w:LsdException> <w:LsdException Locked="false" Priority="66" SemiHidden="false" UnhideWhenUsed="false" Name="Medium List 2"></w:LsdException> <w:LsdException Locked="false" Priority="67" SemiHidden="false" UnhideWhenUsed="false" Name="Medium Grid 1"></w:LsdException> <w:LsdException Locked="false" Priority="68" SemiHidden="false" UnhideWhenUsed="false" Name="Medium Grid 2"></w:LsdException> <w:LsdException Locked="false" Priority="69" SemiHidden="false" UnhideWhenUsed="false" Name="Medium Grid 3"></w:LsdException> <w:LsdException Locked="false" Priority="70" SemiHidden="false" UnhideWhenUsed="false" Name="Dark List"></w:LsdException> <w:LsdException Locked="false" Priority="71" SemiHidden="false" UnhideWhenUsed="false" Name="Colorful Shading"></w:LsdException> <w:LsdException Locked="false" Priority="72" SemiHidden="false" UnhideWhenUsed="false" Name="Colorful List"></w:LsdException> <w:LsdException Locked="false" Priority="73" SemiHidden="false" UnhideWhenUsed="false" Name="Colorful Grid"></w:LsdException> <w:LsdException Locked="false" Priority="60" SemiHidden="false" UnhideWhenUsed="false" Name="Light Shading Accent 1"></w:LsdException> <w:LsdException Locked="false" Priority="61" SemiHidden="false" UnhideWhenUsed="false" Name="Light List Accent 1"></w:LsdException> <w:LsdException Locked="false" Priority="62" SemiHidden="false" UnhideWhenUsed="false" Name="Light Grid Accent 1"></w:LsdException> <w:LsdException Locked="false" Priority="63" SemiHidden="false" UnhideWhenUsed="false" Name="Medium Shading 1 Accent 1"></w:LsdException> <w:LsdException Locked="false" Priority="64" SemiHidden="false" UnhideWhenUsed="false" Name="Medium Shading 2 Accent 1"></w:LsdException> <w:LsdException Locked="false" Priority="65" SemiHidden="false" UnhideWhenUsed="false" Name="Medium List 1 Accent 1"></w:LsdException> <w:LsdException Locked="false" UnhideWhenUsed="false" Name="Revision"></w:LsdException> <w:LsdException Locked="false" Priority="34" SemiHidden="false" UnhideWhenUsed="false" QFormat="true" Name="List Paragraph"></w:LsdException> <w:LsdException Locked="false" Priority="29" SemiHidden="false" UnhideWhenUsed="false" QFormat="true" Name="Quote"></w:LsdException> <w:LsdException Locked="false" Priority="30" SemiHidden="false" UnhideWhenUsed="false" QFormat="true" Name="Intense Quote"></w:LsdException> <w:LsdException Locked="false" Priority="66" SemiHidden="false" UnhideWhenUsed="false" Name="Medium List 2 Accent 1"></w:LsdException> <w:LsdException Locked="false" Priority="67" SemiHidden="false" UnhideWhenUsed="false" Name="Medium Grid 1 Accent 1"></w:LsdException> <w:LsdException Locked="false" Priority="68" SemiHidden="false" UnhideWhenUsed="false" Name="Medium Grid 2 Accent 1"></w:LsdException> <w:LsdException Locked="false" Priority="69" SemiHidden="false" UnhideWhenUsed="false" Name="Medium Grid 3 Accent 1"></w:LsdException> <w:LsdException Locked="false" Priority="70" SemiHidden="false" UnhideWhenUsed="false" Name="Dark List Accent 1"></w:LsdException> <w:LsdException Locked="false" Priority="71" SemiHidden="false" UnhideWhenUsed="false" Name="Colorful Shading Accent 1"></w:LsdException> <w:LsdException Locked="false" Priority="72" SemiHidden="false" UnhideWhenUsed="false" Name="Colorful List Accent 1"></w:LsdException> <w:LsdException Locked="false" Priority="73" SemiHidden="false" UnhideWhenUsed="false" Name="Colorful Grid Accent 1"></w:LsdException> <w:LsdException Locked="false" Priority="60" SemiHidden="false" UnhideWhenUsed="false" Name="Light Shading Accent 2"></w:LsdException> <w:LsdException Locked="false" Priority="61" SemiHidden="false" UnhideWhenUsed="false" Name="Light List Accent 2"></w:LsdException> <w:LsdException Locked="false" Priority="62" SemiHidden="false" UnhideWhenUsed="false" Name="Light Grid Accent 2"></w:LsdException> <w:LsdException Locked="false" Priority="63" SemiHidden="false" UnhideWhenUsed="false" Name="Medium Shading 1 Accent 2"></w:LsdException> <w:LsdException Locked="false" Priority="64" SemiHidden="false" UnhideWhenUsed="false" Name="Medium Shading 2 Accent 2"></w:LsdException> <w:LsdException Locked="false" Priority="65" SemiHidden="false" UnhideWhenUsed="false" Name="Medium List 1 Accent 2"></w:LsdException> <w:LsdException Locked="false" Priority="66" SemiHidden="false" UnhideWhenUsed="false" Name="Medium List 2 Accent 2"></w:LsdException> <w:LsdException Locked="false" Priority="67" SemiHidden="false" UnhideWhenUsed="false" Name="Medium Grid 1 Accent 2"></w:LsdException> <w:LsdException Locked="false" Priority="68" SemiHidden="false" UnhideWhenUsed="false" Name="Medium Grid 2 Accent 2"></w:LsdException> <w:LsdException Locked="false" Priority="69" SemiHidden="false" UnhideWhenUsed="false" Name="Medium Grid 3 Accent 2"></w:LsdException> <w:LsdException Locked="false" Priority="70" SemiHidden="false" UnhideWhenUsed="false" Name="Dark List Accent 2"></w:LsdException> <w:LsdException Locked="false" Priority="71" SemiHidden="false" UnhideWhenUsed="false" Name="Colorful Shading Accent 2"></w:LsdException> <w:LsdException Locked="false" Priority="72" SemiHidden="false" UnhideWhenUsed="false" Name="Colorful List Accent 2"></w:LsdException> <w:LsdException Locked="false" Priority="73" SemiHidden="false" UnhideWhenUsed="false" Name="Colorful Grid Accent 2"></w:LsdException> <w:LsdException Locked="false" Priority="60" SemiHidden="false" UnhideWhenUsed="false" Name="Light Shading Accent 3"></w:LsdException> <w:LsdException Locked="false" Priority="61" SemiHidden="false" UnhideWhenUsed="false" Name="Light List Accent 3"></w:LsdException> <w:LsdException Locked="false" Priority="62" SemiHidden="false" UnhideWhenUsed="false" Name="Light Grid Accent 3"></w:LsdException> <w:LsdException Locked="false" Priority="63" SemiHidden="false" UnhideWhenUsed="false" Name="Medium Shading 1 Accent 3"></w:LsdException> <w:LsdException Locked="false" Priority="64" SemiHidden="false" UnhideWhenUsed="false" Name="Medium Shading 2 Accent 3"></w:LsdException> <w:LsdException Locked="false" Priority="65" SemiHidden="false" UnhideWhenUsed="false" Name="Medium List 1 Accent 3"></w:LsdException> <w:LsdException Locked="false" Priority="66" SemiHidden="false" UnhideWhenUsed="false" Name="Medium List 2 Accent 3"></w:LsdException> <w:LsdException Locked="false" Priority="67" SemiHidden="false" UnhideWhenUsed="false" Name="Medium Grid 1 Accent 3"></w:LsdException> <w:LsdException Locked="false" Priority="68" SemiHidden="false" UnhideWhenUsed="false" Name="Medium Grid 2 Accent 3"></w:LsdException> <w:LsdException Locked="false" Priority="69" SemiHidden="false" UnhideWhenUsed="false" Name="Medium Grid 3 Accent 3"></w:LsdException> <w:LsdException Locked="false" Priority="70" SemiHidden="false" UnhideWhenUsed="false" Name="Dark List Accent 3"></w:LsdException> <w:LsdException Locked="false" Priority="71" SemiHidden="false" UnhideWhenUsed="false" Name="Colorful Shading Accent 3"></w:LsdException> <w:LsdException Locked="false" Priority="72" SemiHidden="false" UnhideWhenUsed="false" Name="Colorful List Accent 3"></w:LsdException> <w:LsdException Locked="false" Priority="73" SemiHidden="false" UnhideWhenUsed="false" Name="Colorful Grid Accent 3"></w:LsdException> <w:LsdException Locked="false" Priority="60" SemiHidden="false" UnhideWhenUsed="false" Name="Light Shading Accent 4"></w:LsdException> <w:LsdException Locked="false" Priority="61" SemiHidden="false" UnhideWhenUsed="false" Name="Light List Accent 4"></w:LsdException> <w:LsdException Locked="false" Priority="62" SemiHidden="false" UnhideWhenUsed="false" Name="Light Grid Accent 4"></w:LsdException> <w:LsdException Locked="false" Priority="63" SemiHidden="false" UnhideWhenUsed="false" Name="Medium Shading 1 Accent 4"></w:LsdException> <w:LsdException Locked="false" Priority="64" SemiHidden="false" UnhideWhenUsed="false" Name="Medium Shading 2 Accent 4"></w:LsdException> <w:LsdException Locked="false" Priority="65" SemiHidden="false" UnhideWhenUsed="false" Name="Medium List 1 Accent 4"></w:LsdException> <w:LsdException Locked="false" Priority="66" SemiHidden="false" UnhideWhenUsed="false" Name="Medium List 2 Accent 4"></w:LsdException> <w:LsdException Locked="false" Priority="67" SemiHidden="false" UnhideWhenUsed="false" Name="Medium Grid 1 Accent 4"></w:LsdException> <w:LsdException Locked="false" Priority="68" SemiHidden="false" UnhideWhenUsed="false" Name="Medium Grid 2 Accent 4"></w:LsdException> <w:LsdException Locked="false" Priority="69" SemiHidden="false" UnhideWhenUsed="false" Name="Medium Grid 3 Accent 4"></w:LsdException> <w:LsdException Locked="false" Priority="70" SemiHidden="false" UnhideWhenUsed="false" Name="Dark List Accent 4"></w:LsdException> <w:LsdException Locked="false" Priority="71" SemiHidden="false" UnhideWhenUsed="false" Name="Colorful Shading Accent 4"></w:LsdException> <w:LsdException Locked="false" Priority="72" SemiHidden="false" UnhideWhenUsed="false" Name="Colorful List Accent 4"></w:LsdException> <w:LsdException Locked="false" Priority="73" SemiHidden="false" UnhideWhenUsed="false" Name="Colorful Grid Accent 4"></w:LsdException> <w:LsdException Locked="false" Priority="60" SemiHidden="false" UnhideWhenUsed="false" Name="Light Shading Accent 5"></w:LsdException> <w:LsdException Locked="false" Priority="61" SemiHidden="false" UnhideWhenUsed="false" Name="Light List Accent 5"></w:LsdException> <w:LsdException Locked="false" Priority="62" SemiHidden="false" UnhideWhenUsed="false" Name="Light Grid Accent 5"></w:LsdException> <w:LsdException Locked="false" Priority="63" SemiHidden="false" UnhideWhenUsed="false" Name="Medium Shading 1 Accent 5"></w:LsdException> <w:LsdException Locked="false" Priority="64" SemiHidden="false" UnhideWhenUsed="false" Name="Medium Shading 2 Accent 5"></w:LsdException> <w:LsdException Locked="false" Priority="65" SemiHidden="false" UnhideWhenUsed="false" Name="Medium List 1 Accent 5"></w:LsdException> <w:LsdException Locked="false" Priority="66" SemiHidden="false" UnhideWhenUsed="false" Name="Medium List 2 Accent 5"></w:LsdException> <w:LsdException Locked="false" Priority="67" SemiHidden="false" UnhideWhenUsed="false" Name="Medium Grid 1 Accent 5"></w:LsdException> <w:LsdException Locked="false" Priority="68" SemiHidden="false" UnhideWhenUsed="false" Name="Medium Grid 2 Accent 5"></w:LsdException> <w:LsdException Locked="false" Priority="69" SemiHidden="false" UnhideWhenUsed="false" Name="Medium Grid 3 Accent 5"></w:LsdException> <w:LsdException Locked="false" Priority="70" SemiHidden="false" UnhideWhenUsed="false" Name="Dark List Accent 5"></w:LsdException> <w:LsdException Locked="false" Priority="71" SemiHidden="false" UnhideWhenUsed="false" Name="Colorful Shading Accent 5"></w:LsdException> <w:LsdException Locked="false" Priority="72" SemiHidden="false" UnhideWhenUsed="false" Name="Colorful List Accent 5"></w:LsdException> <w:LsdException Locked="false" Priority="73" SemiHidden="false" UnhideWhenUsed="false" Name="Colorful Grid Accent 5"></w:LsdException> <w:LsdException Locked="false" Priority="60" SemiHidden="false" UnhideWhenUsed="false" Name="Light Shading Accent 6"></w:LsdException> <w:LsdException Locked="false" Priority="61" SemiHidden="false" UnhideWhenUsed="false" Name="Light List Accent 6"></w:LsdException> <w:LsdException Locked="false" Priority="62" SemiHidden="false" UnhideWhenUsed="false" Name="Light Grid Accent 6"></w:LsdException> <w:LsdException Locked="false" Priority="63" SemiHidden="false" UnhideWhenUsed="false" Name="Medium Shading 1 Accent 6"></w:LsdException> <w:LsdException Locked="false" Priority="64" SemiHidden="false" UnhideWhenUsed="false" Name="Medium Shading 2 Accent 6"></w:LsdException> <w:LsdException Locked="false" Priority="65" SemiHidden="false" UnhideWhenUsed="false" Name="Medium List 1 Accent 6"></w:LsdException> <w:LsdException Locked="false" Priority="66" SemiHidden="false" UnhideWhenUsed="false" Name="Medium List 2 Accent 6"></w:LsdException> <w:LsdException Locked="false" Priority="67" SemiHidden="false" UnhideWhenUsed="false" Name="Medium Grid 1 Accent 6"></w:LsdException> <w:LsdException Locked="false" Priority="68" SemiHidden="false" UnhideWhenUsed="false" Name="Medium Grid 2 Accent 6"></w:LsdException> <w:LsdException Locked="false" Priority="69" SemiHidden="false" UnhideWhenUsed="false" Name="Medium Grid 3 Accent 6"></w:LsdException> <w:LsdException Locked="false" Priority="70" SemiHidden="false" UnhideWhenUsed="false" Name="Dark List Accent 6"></w:LsdException> <w:LsdException Locked="false" Priority="71" SemiHidden="false" UnhideWhenUsed="false" Name="Colorful Shading Accent 6"></w:LsdException> <w:LsdException Locked="false" Priority="72" SemiHidden="false" UnhideWhenUsed="false" Name="Colorful List Accent 6"></w:LsdException> <w:LsdException Locked="false" Priority="73" SemiHidden="false" UnhideWhenUsed="false" Name="Colorful Grid Accent 6"></w:LsdException> <w:LsdException Locked="false" Priority="19" SemiHidden="false" UnhideWhenUsed="false" QFormat="true" Name="Subtle Emphasis"></w:LsdException> <w:LsdException Locked="false" Priority="21" SemiHidden="false" UnhideWhenUsed="false" QFormat="true" Name="Intense Emphasis"></w:LsdException> <w:LsdException Locked="false" Priority="31" SemiHidden="false" UnhideWhenUsed="false" QFormat="true" Name="Subtle Reference"></w:LsdException> <w:LsdException Locked="false" Priority="32" SemiHidden="false" UnhideWhenUsed="false" QFormat="true" Name="Intense Reference"></w:LsdException> <w:LsdException Locked="false" Priority="33" SemiHidden="false" UnhideWhenUsed="false" QFormat="true" Name="Book Title"></w:LsdException> <w:LsdException Locked="false" Priority="37" Name="Bibliography"></w:LsdException> <w:LsdException Locked="false" Priority="39" QFormat="true" Name="TOC Heading"></w:LsdException> </w:LatentStyles> </xml><![endif]--><!-- [if gte mso 10]> <style> /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin-top:0in; mso-para-margin-right:0in; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0in; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-ansi-language:EN-US; mso-fareast-language:EN-US;} </style> <![endif]--> en-US Journal of Pharmaceutical Research and Opinion 2249-1953 “I ……………………………………….certify that I have participated sufficiently in the conception and design of this work and the analysis of the data (wherever applicable), as well as the writing of the manuscript, to take public responsibility for it. I believe the manuscript represents valid work. I have reviewed the final version of the manuscript and approve it for publication. Neither has the manuscript nor one with substantially similar content under my authorship been published nor is being considered for publication elsewhere, except as described in an attachment. Furthermore I attest that I shall produce the data upon which the manuscript is based for examination by the editors or their assignees, if requested.” http://innovativejournal.in/index.php/jpro/article/view/1324 <p>During<strong> </strong>the Linagliptin process development, several related substances in the range of 0.05% to 0.15% were observed by high performance liquid chromatography [HPLC] method. Liquid chromatography mass spectrometry [LC-MS] study was performed to identify the molecular mass of these impurities. The origin of these impurities was investigated. These impurities<strong><em> </em></strong>were synthetically prepared and characterized by IR, NMR and Mass analyzes. They were co-injected for their further confirmation. These impurities are 8-[(<em>S</em>)-3-Aminopiperidin-1-yl]-7-(but-2-ynyl)-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-1<em>H</em>-purine-2,6(3<em>H</em>,7<em>H</em>)-dione (Impurity-I), 7-(But-2-ynyl)-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-8-(piperidin-3-ylamino)-1<em>H</em>-purine-2,6(3<em>H</em>,7<em>H</em>)-dione (Impurity-II), 8-[(<em>R</em>)-3-Aminopiperidin-1-yl]-3-methyl-1,7-bis((4-methylquinazolin-2-yl)methyl)-1<em>H</em>-purine-2,6(3<em>H</em>,7<em>H</em>)-dione (Impurity-III), 8-[(<em>R</em>)-3-Aminopiperidin-1-yl]-1-(but-2-ynyl)-3-methyl-7-[(4-methylquinazolin-2-yl)methyl]-1<em>H</em>-purine-2,6(3<em>H</em>,7<em>H</em>)-dione (Impurity-IV), 1,7-Di(but-2-ynyl)-3-methyl-8-[(<em>R</em>)-3-(methyleneamino) piperidin -1-yl]-1<em>H</em>-purine-2,6(3<em>H</em>,7<em>H</em>)-dione (Impurity-V), 7-(But-2-ynyl)-8-(dimethylamino)-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-1<em>H</em>-purine-2,6(3<em>H</em>,7<em>H</em>)-dione (Impurity-VI) and  8-[(<em>R</em>)-3-Aminopiperidin-1-yl]-7-[(<em>E</em>)-3-bromobut-2-enyl]-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-1<em>H</em>-purine-2,6(3<em>H</em>,7<em>H</em>)-dione (Impurity-VII).</p> Sukumar Nandi, Akkina Naresh Gona Reddy, Paparaju Venkateswarlu A. Syam Prasad Reddy, K. Shantan Kumar Reddy Copyright (c) 2018 JOURNAL OF RESEARCH & OPINION 2015-05-10 2015-05-10 10.15520/jpro.2015.vol5.iss5.15 http://innovativejournal.in/index.php/jpro/article/view/1325 <p>In response to the Affordable Care Act, innovations are taking place in the healthcare industry to improve patient healthcare and reduce costs. Over the past twenty years, the pharmacy profession has transformed into a position of offering innovative solutions for the nation’s most critical healthcare issues (Johnsen, 2015). Neighborhood pharmacies are becoming the new face of healthcare, with one-on-one consulting, medication dispensing and management, and vaccinations. Remote healthcare monitoring devices (telemedicine), such as the Dyno, can allow patients to take charge of their personal healthcare at home, reducing or eliminating trips to the physician’s office or the hospital. These innovations are leading to more efficiency in healthcare and reductions in healthcare costs, and can provide healthcare to underserved communities.</p> Nik Tehrani Cynthia Meckl-Sloan Copyright (c) 2018 JOURNAL OF RESEARCH & OPINION 2015-05-15 2015-05-15 10.15520/jpro.2015.vol5.iss5.16