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Heading"></w:LsdException> </w:LatentStyles> </xml><![endif]--><!-- [if gte mso 10]> <style> /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin-top:0in; mso-para-margin-right:0in; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0in; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-ansi-language:EN-US; mso-fareast-language:EN-US;} </style> <![endif]--> en-US “I ……………………………………….certify that I have participated sufficiently in the conception and design of this work and the analysis of the data (wherever applicable), as well as the writing of the manuscript, to take public responsibility for it. I believe the manuscript represents valid work. I have reviewed the final version of the manuscript and approve it for publication. Neither has the manuscript nor one with substantially similar content under my authorship been published nor is being considered for publication elsewhere, except as described in an attachment. Furthermore I attest that I shall produce the data upon which the manuscript is based for examination by the editors or their assignees, if requested.” proeditor2011@gamil.com (Santosh dutt) proeditor2011@gmail.com (pharmaceutical sciences) Wed, 13 May 2015 00:00:00 +0000 OJS 3.1.0.1 http://blogs.law.harvard.edu/tech/rss 60 Process Related Impurities In Anti-Diabetic Drug Linagliptin http://innovativejournal.in/index.php/jpro/article/view/1324 <p>During<strong> </strong>the Linagliptin process development, several related substances in the range of 0.05% to 0.15% were observed by high performance liquid chromatography [HPLC] method. Liquid chromatography mass spectrometry [LC-MS] study was performed to identify the molecular mass of these impurities. The origin of these impurities was investigated. These impurities<strong><em> </em></strong>were synthetically prepared and characterized by IR, NMR and Mass analyzes. They were co-injected for their further confirmation. These impurities are 8-[(<em>S</em>)-3-Aminopiperidin-1-yl]-7-(but-2-ynyl)-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-1<em>H</em>-purine-2,6(3<em>H</em>,7<em>H</em>)-dione (Impurity-I), 7-(But-2-ynyl)-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-8-(piperidin-3-ylamino)-1<em>H</em>-purine-2,6(3<em>H</em>,7<em>H</em>)-dione (Impurity-II), 8-[(<em>R</em>)-3-Aminopiperidin-1-yl]-3-methyl-1,7-bis((4-methylquinazolin-2-yl)methyl)-1<em>H</em>-purine-2,6(3<em>H</em>,7<em>H</em>)-dione (Impurity-III), 8-[(<em>R</em>)-3-Aminopiperidin-1-yl]-1-(but-2-ynyl)-3-methyl-7-[(4-methylquinazolin-2-yl)methyl]-1<em>H</em>-purine-2,6(3<em>H</em>,7<em>H</em>)-dione (Impurity-IV), 1,7-Di(but-2-ynyl)-3-methyl-8-[(<em>R</em>)-3-(methyleneamino) piperidin -1-yl]-1<em>H</em>-purine-2,6(3<em>H</em>,7<em>H</em>)-dione (Impurity-V), 7-(But-2-ynyl)-8-(dimethylamino)-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-1<em>H</em>-purine-2,6(3<em>H</em>,7<em>H</em>)-dione (Impurity-VI) and  8-[(<em>R</em>)-3-Aminopiperidin-1-yl]-7-[(<em>E</em>)-3-bromobut-2-enyl]-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-1<em>H</em>-purine-2,6(3<em>H</em>,7<em>H</em>)-dione (Impurity-VII).</p> Sukumar Nandi, Akkina Naresh Gona Reddy, Paparaju Venkateswarlu A. Syam Prasad Reddy, K. Shantan Kumar Reddy ##submission.copyrightStatement## http://innovativejournal.in/index.php/jpro/article/view/1324 Sun, 10 May 2015 00:00:00 +0000 Community Pharmacies, the Future of Healthcare in the U.S. http://innovativejournal.in/index.php/jpro/article/view/1325 <p>In response to the Affordable Care Act, innovations are taking place in the healthcare industry to improve patient healthcare and reduce costs.  Over the past twenty years, the pharmacy profession has transformed into a position of offering innovative solutions for the nation’s most critical healthcare issues (Johnsen, 2015).  Neighborhood pharmacies are becoming the new face of healthcare, with one-on-one consulting, medication dispensing and management, and vaccinations.  Remote healthcare monitoring devices (telemedicine), such as the Dyno, can allow patients to take charge of their personal healthcare at home, reducing or eliminating trips to the physician’s office or the hospital.  These innovations are leading to more efficiency in healthcare and reductions in healthcare costs, and can provide healthcare to underserved communities.</p> Nik Tehrani, Cynthia Meckl-Sloan ##submission.copyrightStatement## http://innovativejournal.in/index.php/jpro/article/view/1325 Fri, 15 May 2015 00:00:00 +0000