Innovative Journal Journal of Medical Biomedical and Applied Sciences 2277:4939 10 04 Retrospective Study of Procalcitonin, Antibiotics Usage & Outcome in Sepsis at Tertiary Healthcare Center in Maharashtra. 1 Dr Sudhir Deshpande (Chief Intensivist) Dr. Hedgewar Hospital, Aurangabd-431005, Maharashtra, India Journal Article https://doi.org/10.15520/ijmhs.v10i03.282 Abstract Serum Procalcitonin (PCT) is a biomarker and it is widely studied to guide antibiotic treatment in septic patients. This study considered the diagnostic benefit of PCT in sepsis or septic shock patient and how serum PCT will impact on antibiotic intervention. PCT level was examined at baseline and regular interval to manage the antibiotics. After PCT implementation 82.48% patients were discharged and it also decreased hospital stay. We conclude that there was a significant decreased in extra use of broad spectrum antibiotics; length of stay in hospital, cost of hospitalization after the implementation of PCT. PCT values had a higher predictive usefulness for proper management of sepsis and decrease use of antibiotics. 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