Innovative Journal Journal of Medical Biomedical and Applied Sciences 2277:4939 10 06 Various applications of microbial biosurfactant in the field of medical Sciences 1 Arun Kumar Pradhan Assistant Professor, Centre for Biotechnology, Siksha ‘O’ Anusandhan, (Deemed to be University) Bhubaneswar, Odisha- 751003, India Nibhashree Nath Centre for Biotechnology, Siksha O Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India Shree Tripathy Centre for Biotechnology, Siksha O Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India Journal Article https://doi.org/10.15520/ijmhs.v10i03.286 Abstract Amphipathic nature of biosurfactants enhances their applications in various field like health care, bioremediation, agriculture, mining. Biosurfactants can interact with hydrophilic surface as well as hydrophobic surface. As plasma membrane is made up of lipid bilayer, it is very easy for biosurfactant to diffuse into it and show its activity. So it is used as drug for many disorder and used as vehicle (liposome) to deliver dugs into body. In this study, different chemical nature and various medical applications of biosurfactants are reviewed. Antibacterial property of biosurfactant isolated from different species of Lactobacillus and Bacillus are reviewed. Effect of monoolein on cervical cancer (HeLA) and leukemia (U937) cells are studied. Antifouling, antifungal and antiviral nature of biosurfactant are also studied. This paper also focused on application of biosurfactant in nanotechnology, food industry and cosmetic industry. 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