Innovative Journal Journal of Medical Biomedical and Applied Sciences 2277:4939 10 06 A REVIEW ON SUBMUCOSAL ADMINISTRATION OF CORTICOSTEROIDS IN THIRD MOLAR SURGERY 1 Janani Kandamani Post Graduate Student, Department of Oral and Maxillofacial Surgery, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, No 162, Poonamallee High Road, Vellappanchavadi, Chennai-600077, Tamil Nadu, India Divya S. R Post graduate student, Department of Oral and Maxillofacial Surgery, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, No 162, Poonamallee High Road, Vellappanchavadi, Chennai-600077, Tamil Nadu, India Journal Article https://doi.org/10.15520/ijmhs.v10i03.284 Abstract The classic signs of inflammation, which includes edema, erythema, pain and loss of function, commonly occurs after a routine or difficult third molar surgical procedure. The inflammatory process is necessary for the healing to occur, but often excessive inflammation which causes the patient unnecessary pain, trismus and edema. Corticosteroids reduce inflammation via the inhibition of phospholipase A2, which is the first enzyme involved in the conversion of phospholipids into arachidonic acid, therefore blocking the synthesis of other products such as prostaglandins, leukotrienes and substances related to thromboxane A2. In essence, corticosteroids prevents the formation of these end products which is a broth of potent inflammatory mediators causing the signs and symptoms. This articles has focussed to review on submucosal administration of corticosteroids in third molar surgery. 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