Innovative Journal Journal of Medical Biomedical and Applied Sciences 2277:4939 10 06 Evaluation and Comparison of Antioxidant status in ischemic and haemorrhagic cases of stroke 1 Rahul Kumar Shukla PhD Research Scholar, Index Medical College & P.G. Institute, Indore B.K. Agrawal Prof. and HOD, Index Medical College & P.G. Institute, Indore. Amit Kumar Assistant Professor, Department of Medicine, Govt. Medical College, Azamgarh Journal Article DOI: https://doi.org/10.15520/ijmhs.v10i03.285 Abstract Introduction: The World health organization (WHO) has well-defined stroke as “rapidly progression of clinical signs of focal and at times global disturbances of cerebral function long-lasting > 24 hours or resulting of death, with no apparent reason other than vascular region.” Material and Methods This case-control study was conducted on an overall population of 200 individuals (58 ischemic strokes and 29 haemorrhagic strokes as the case groups; 58 healthy individuals as the control group). Diagnosis: The diagnosis of stroke was based on history and clinical examination and brain CT scan were used to confirm and classify ischemic and haemorrhagic stroke cases. Results: A total of 200 cases of stroke (58 ischemic stroke, 29 haemorrhagic strokes, and 58 healthy individuals as the control group) were identified during the study follow-up. GPX levels are reduced significantly in ISPs and HSPs equated with control subjects(p<0.001). Extreme decrease in GPX is seen in ISPs than HSPs(p<0.001). Conclusion Finally, positive direct relationship was seen in MDA along with infarct size. So, it could consider as a bio marker for recognising stroke. This could be valued for improving the dose frequency for improvement of patient health. From these studies, we can conclude that antioxidant defence is reduced in ischemic stroke patients as a significance of inclined oxidative stress. 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