Innovative Journal Journal of Medical Biomedical and Applied Sciences 2277:4939 10 06 Signet ring clear cell variant of Calcifying Epithelial OdontogenicTumour: A Rare histopathological Presentation 1 Dr. Sudhakara M Reader, Department of Oral and Maxillofacial Pathology, Krishnadevaraya College of Dental Sciences & Hospital, Bangalore Dr. Radhika M Bavle Prof and HOD, Department of Oral and Maxillofacial Pathology, Krishnadevaraya College of Dental Sciences & Hospital, Bangalore Dr. Paremala K Asst. Professor, Department of Oral Pathology, Govt Dental College and Hospital, Afzalgunj, Hyderabad Dr. Soumya M Reader, Department of Oral and Maxillofacial Pathology, Krishnadevaraya College of Dental Sciences & Hospital, Bangalore Journal Article https://doi.org/10.15520/ijmhs.v10i03.286 Abstract Calcifying epithelial odontogenic tumour (CEOT) is an uncommon, benign, odontogenic neoplasm that is epithelial in origin. It accounts for 1% of all the odontogenic tumors of the jaws. Conventionally, CEOT on histological examination exhibits sheets and islands of polyhedral cells with abundant finely granular eosinophilic cytoplasm with well-defined cytoplasmic borders and prominent intercellular bridges. Characteristic homogenous eosinophilic amyloid and calcifications either focally or in the form of liesegang rings are noted frequently. Various histologic variants have been described; among which clear cell variant is a rare one. Here we present an unusual case of intraosseous large CEOT with signet ring clear cells. Tabangay-Lim, Ida Marie, Mallari, Raymund Noel C., Lacsamana, Noelito M., Paz, Dexter Domingo Z., Villafuerte, Arthur Rico R., Quilendrino, Peter Raymund M., Recurrent calcifying epithelial odontogenic tumor (Pindborg tumor): A case study, Oral Oncology Extra, 2005, 41, 10, 259, 266, 1741-9409, 10.1016/j.ooe.2005.04.006, Elsevier BV, https://dx.doi.org/10.1016/j.ooe.2005.04.006 Pindborg, J. J., The Calcifying Epithelial Odontogenic Tumor. Review of Literature and Report of An Extra-Osseous Case, Acta Odontologica Scandinavica, 1966, 24, 4, 419, 430, 0001-6357, 1502-3850, 10.3109/00016356609028230, Informa UK Limited, https://dx.doi.org/10.3109/00016356609028230 Hicks, M. John, Flaitz, Catherine M., Wong, Mark E. K., McDaniel, R. Keith, Cagle, Philip T., Clear cell variant of calcifying epithelial odontogenic tumor: Case report and review of the literature, Head & Neck, 1994, 16, 3, 272, 277, 1043-3074, 1097-0347, 10.1002/hed.2880160311, Wiley, https://dx.doi.org/10.1002/hed.2880160311 Rangel, Alca, Da Silva, A A, Ito, F A, Lopes, M A, De Almeida, O P, Vargas, P A, Clear cell variant of calcifying epithelial odontogenic tumour: is it locally aggressive?, J Oral Maxillofac Surg, 2009, 67, 207, 218 Rajendran, R, Shivapathasundaram, B, Shafer’s Textbook of Oral Pathology, fifth Ed, Elsevier - A division of Reed Elsevier India Pvt Ltd, Noida, 2006 Bilodeau, E A, Weinreb, I, Antonescu, C R, Zhang, L, Dacic, S, Muller, S, Clear cell odontogenic carcinomas show EWSR1 rearrangements. A novel finding and a biological link to salivary clear cell carcinomas, Am J Surg Pathol, 2013, 37, 1001, 1006 Philipsen, H.P, Reichart, P.A, Calcifying epithelial odontogenic tumour: biological profile based on 181 cases from the literature, Oral Oncology, 2000, 36, 1, 17, 26, 1368-8375, 10.1016/s1368-8375(99)00061-5, Elsevier BV, https://dx.doi.org/10.1016/s1368-8375(99)00061-5 Anavi, Yakir, Kaplan, Ilana, Citir, Mete, Calderon, Shlomo, Clear-cell variant of calcifying epithelial odontogenic tumor: Clinical and radiographic characteristics, Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 2003, 95, 332, 339, 1079-2104, Elsevier BV, 10.1067/moe.2003.8, https://dx.doi.org/10.1067/moe.2003.8 Goode, Robert K, Calcifying epithelial odontogenic tumor, Oral and Maxillofacial Surgery Clinics of North America, 2004, 16, 3, 323, 331, 1042-3699, 10.1016/j.coms.2004.03.002, Elsevier BV, https://dx.doi.org/10.1016/j.coms.2004.03.002 Yamaguchi, A, Kokubu, J M, Takagi, M, Ishikawa, G, calcifying epithelial odontogenic tumor: Histochemical and electron microscopic observations on a case, 1980, 27, 129, 164 Abrams, Albert M., Howell, Francis V., Calcifying epithelial odontogenic tumor: report of four cases, The Journal of the American Dental Association, 1967, 74, 6, 1231, 1240, 0002-8177, 10.14219/jada.archive.1967.0426, Elsevier BV, https://dx.doi.org/10.14219/jada.archive.1967.0426 Reichart, P A, Philipsen, H P, Odontogenic tumors and Allied lesions, Quintessence Publishing, London, 2004 White, Pharoah, Oral radiology-principles and Interpretations, Elsevier, India, 1994 Bouckaert, M.M.R., Raubenheimer, E.J., Jacobs, F.J., Calcifying epithelial odontogenic tumor with intracranial extension: Report of a case and review of the literature, Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 2000, 90, 656, 662, 1079-2104, Elsevier BV, 10.1067/moe.2000.106577, https://dx.doi.org/10.1067/moe.2000.106577 Thomas, Jincy, Thomas, Valsa, Kumar, NileenaR, Sharafuddeen, Clear cell calcifying epithelial odontogenic tumor: A rare case report, Journal of Indian Academy of Oral Medicine and Radiology, 2008, 20, 1, 28, 28, 0972-1363, 10.4103/0972-1363.44358, Medknow, https://dx.doi.org/10.4103/0972-1363.44358 Habibi, Ataollah, Saghravanian, Nasrollah, Zare, Reza, Jafarzadeh, Hamid, Clear cell variant of extraosseous calcifying epithelial odontogenic tumor: a case report, Journal of Oral Science, 2009, 51, 3, 485, 488, 1343-4934, 1880-4926, 10.2334/josnusd.51.485, Nihon University School of Dentistry, https://dx.doi.org/10.2334/josnusd.51.485 Gaiger de Oliveira, Márcia, Chaves, Anna Cecília Moraes, Visioli, Fernanda, Rojas, Elisabete Ulsenheimer, Moure, Sabrina Pozatti, Romanini, Juliana, de A. Mariath, Jorge Ernesto, Rados, Pantelis Varvaki, Filho, Manoel Sant′ana, Peripheral clear cell variant of calcifying epithelial odontogenic tumor affecting 2 sites: report of a case, Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 2009, 107, 407, 411, 1079-2104, Elsevier BV, 10.1016/j.tripleo.2008.11.004, https://dx.doi.org/10.1016/j.tripleo.2008.11.004 Takata, T., Ogawa, I., Miyauchi, M., Ijuhin, N., Nikai, H., Fujita, M., Non-calcifying Pindborg tumor with Langerhans cells, Journal of Oral Pathology and Medicine, 1993, 22, 8, 378, 383, 0904-2512, 1600-0714, 10.1111/j.1600-0714.1993.tb01093.x, Wiley, https://dx.doi.org/10.1111/j.1600-0714.1993.tb01093.x De Augiar, Mcf, Gomez, R S, Silva, E C, De Araujo, V C, Clear cell ameloblastoma (clear cell odontogenic carcinoma): report of a case. Oral Surg Oral Med Oral Pathol, 1996, 81, 79, 83 Gadodia, Prakash, Wadhwani, Ritesh, Murgod, Vinita, Vinodkuma, M P, Panda, Arun, Sabni, Rajesh, Clear Cell Variant of Extraosseous Calcifying Epithelial Odontogenic Tumor: Report of a Case and Review of Literature, Journal of International Oral Health, 2016, 8, 973, 977