Innovative Journal Journal of Medical Biomedical and Applied Sciences 2277:4939 10 07 Attenuation of sympathetic response to laryngoscopy and endotracheal intubation in patients undergoing laparoscopic cholecystectomy: a comparative study between esmolol and dexmedetomidine 1 Dr Meyong P Bhutia Associate Professor, Department of Anaesthesia, SMIMS, Gangtok Dr Arati Rai 2.Associate Professor, Department of Anaesthesia, SMIMS, Gangtok Journal Article Abstract Introduction: Attenuation of sympathetic response in response to laryngoscopy and intubation is vital for smooth induction of general anaesthesia in patients undergoing a surgical procedure. Various methods have been used by the anaesthetist to control this sympathetic response with varying degree of success. The drug profile of esmolol and dexmedetomidine seems to be ideally suited to attenuate this haemodynamic response and hence have been considered for this study. Aim: to compare the effectiveness of esmolol and dexmedetomidine in attenuating the haemodynamic response to laryngoscopy and endotracheal intubation when used in bolus dosing regimen in surgical patients undergoing laparoscopic cholecystectomy under general anaesthesia. Materials and Methods: ASA I&II patients between the age of 20 -60 years undergoing laparoscopic cholecystectomy under general anaesthesia were enrolled in the study after obtaining written consent from them. A sample size of 80 patients was drawn which was randomly divided into two groups (E &D) of 40 patients each. Group E received esmolol in a dose of 1mg/kg which was injected slowly over 30 seconds while Group D received dexmedetomidine in a dose of 0.75ug/kg given over 10 minutes. Induction of anaesthesia was done once the study drug was given. The recording was done for changes in haemodynamic parameters during laryngoscopy and intubation and any incidence of adverse events arising as a result of administration of study drug. Data of the two groups were analysed using student t-test and chi-square test with p-Value of <0.05 statistically significant. Results: Both esmolol and dexmedetomidine are capable of attenuating the sympathetic response to laryngoscopy and intubation. However, compared to esmolol, dexmedetomidine was able to produce statistically significant attenuation of this sympathetic response. Data for haemodynamic parameters at 2minutes and 4 minutes after giving the study drug was statistically significant for Group D compared to Group E, during which time laryngoscopy and endotracheal intubation were being done. The incidences of adverse events were negligible in Group D compared to Group E. 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