Innovative Journal Innovative Journal of Medical and Health Science 2589-9341 10 07 2020 7 15 Factors affecting urine leak after percutaneous nephrolithotomy: a single centre prospective study 1 Dineshan K.M Government Medical College, Calicut Madhavan N Government Medical College, Calicut Sumit More Government Medical College, Calicut Edikkula Varghese Government Medical College, Calicut Vaibhav Vishal Government Medical College, Calicut Felix S Cardosa Government Medical College, Calicut Journal Article https://doi.org/10.15520/ijmhs.v10i07.3038 Abstract Aim; We aim to determine the factors that affect urine leak after a successful PCNL. Material and Methods; All patients who underwent PCNL from January 2016 to December 2017 at our institution were evaluated prospectively.Stones of size >or=2cm in largest diameter and stones>or=1.5 in the lower calyx not amenable to ESWL or stone of any size resistant to ESWL were selected for PCNL.Those who were not willing to be included in the study, patients with history of PCNL in the same kidney were excluded from the study. Results; There was a clear association between hydronephrosis and prolonged duration of leakage with group 2 showing 30 out of 31 patients having grade 1or more hydronephrosis, presence of intraparenchymal pelvis and renal parenchymal thickness in the access line were also predictive of prolonged leak.By regression analysis,renal parenchymal thickness<13.95+or-3.48 was found to be associated with increased leak. Conclusion; Grade of hydronephrosis, intraparenchymal pelvis and parenchymal thickness in access line are associated with prolonged urine leak.We recommend the use of double J stent during PCNL in the presence of these factors. 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