Oxidative Stress and Coronary Stenting

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K. S. S. M. G. Santhosh S, “Oxidative Stress and Coronary Stenting”, ijmhs, vol. 5, no. 4, pp. 146–149, Aug. 2015.
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Abstract

Introduction: Percutaneous intervention compared to CABG has become commonly used treatment for symptomatic coronary artery disease. Various factors are shown to affect the outcome of stenting in a patient. This study was done to determine the changes that occur in oxidative stress parameters and its relation with coronary stent outcome during follow-up. Subjects and Methods: 57 patients were successfully followed up for six months for cardiac related adverse events. Blood samples were collected for serial measurements of Catalase, serum malondialdehyde, protein carbonylation and total antioxidant levels.  Results: When compared with baseline [23.81±19.39 µmol/L] level, MDA showed a significant decrease after the procedure [11.91±9.78 µmol/L] which increased after 24 hours [18.06±16.54 µmol/L]and after 72 hours [20.81±18.11 µmol/L]. Catalase showed increase after 24 hours of procedure [33.62±16.00 U/L] when compared with baseline [7.91±5.66 U/L] which decreased at 72 hours [24.60±11.20 U/L] significantly, though it remained high compared to baseline. During follow up of six months four patients developed adverse cardiac events. Discussion: We conclude that PCI procedure is associated with injury to vessel wall which results in oxidative injury and this may contribute to restenosis and reinfarction

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