A CLINICAL STUDY TO COMPARE THE EASE OF INTUBATION WITH COMBINATION OF SEVOFLURANE AND PROPOFOL WITH PROPOFOL ALONE

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R. T. *, Y. N. Radha M K, Madhu R, “A CLINICAL STUDY TO COMPARE THE EASE OF INTUBATION WITH COMBINATION OF SEVOFLURANE AND PROPOFOL WITH PROPOFOL ALONE”, ijmhs, vol. 3, no. 3, Oct. 2013.
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Abstract

Endotracheal intubation is the most important and crucial step during administration of general anaesthesia. Intubation using short-acting hypnotic drug is frequently facilitated by the administration of a depolarizing relaxant such as succinylcholine. However, succinylcholine administration may be associated, with well known side effects. Even the use of non-depolarizing relaxants may be associated with undesirable effects such as prolonged neuromuscular blockage. Propofol is a short-acting intravenous anaesthetic that has been widely used as an induction agent. However, if used alone has been associated with several adverse effects, including hypotension, pain on injection, and excitatory motor movements. Potent inhalation agents can be used as an alternative to facilitate tracheal intubation. Until the introduction of sevoflurane, halothane was the most commonly used agent for inhalation induction. Hence an attempt was made with a combination of Sevoflurane with reduced dosage of Propofol for intubation to evaluate intubation conditions, hemodynamic responses and side effects. Methodology: After obtaining a written informed consent and ethical clearance, a prospective study was performed on ASA I patients aged between 20-40 years posted for various surgical procedures. Result: Intubating conditions were excellent in combination group (p<0.001). There was definite reduction in heart rate and arterial pressure in propofol alone group. Induction time is significantly more in combination group and there was no significant difference in side-effects between the groups. Conclusion: we concluded that combination of sevoflurane and propofol is superior to IV propofol alone with respect to quality of intubation. And can also be attempted for anticipated difficult airway intubation.

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