Background: Osteoarthritis of knee and/or hip joints is a common disorder associated with a significant morbidity in the elderly patients. Celecoxib + Diacerein Fixed Dose Combination (FDC) can be a useful medication for the treatment of osteoarthritis of knee and/or hip joints. Objective: To compare efficacy and safety of Celecoxib + Diacerein FDC capsules given twice daily with Aceclofenac + Diacerein FDC tablets given twice daily in the management of osteoarthritis of knee and/or hip joints in adult Indian patients. Methods: Clinically symptomatic patients with osteoarthritis of knee and/or hip joints were randomized to treatment with Celecoxib 100 mg + Diacerein 50 mg FDC capsules or Aceclofenac 100 mg + Diacerein 50 mg FDC tablets each given twice daily for 4 weeks in this comparative clinical trial. Efficacy assessments were carried out using pre-validated SAS (Short Arthritis Assessment Scale) questionnaire. Results: Celecoxib + Diacerein FDC capsules (n=12) produced significant improvement in Pain, Physical Function & Overall well-being aspects of SAS questionnaire at the end of treatment period as compared to baseline (p<0.05 for all). Similar results were obtained with Aceclofenac + Diacerein FDC tablets (n=13); there was no statistically significant difference between the two treatment groups. Celecoxib + Diacerein FDC capsules were excellently tolerated and none of the patients enrolled in either of the groups reported any adverse event. Conclusion: Celecoxib + Diacerein FDC capsules are equally efficacious as Aceclofenac + Diacerein FDC tablets and excellently tolerated for the treatment of osteoarthritis of knee and/or hip joints in adult Indian patients.
Introduction: Antimicrobial resistance(AMR) has emerged as a major public health problem all over the world. Infections caused by resistant microbes fail to respond to treatment, resulting in prolonged illness and greater risk of death. Treatment failures also lead to longer periods of infectivity, with increased numbers of infected people moving in the community. This in turn exposes the general population to the risk of contracting a resistant strain of microorganisms. Thus antibiotic susceptibility patterns were conducted. Material And Methods: One hundred and eighty four samples obtained from sputum, throat, blood, urine, pus, stool and ear swab. Among them 84 were reported the presence of bacterial infection. Culture examination was carried out using blood agar and MacConkeyâ€™s medium, followed by inoculation by four flame streak method. Antibiotic susceptibility was confirmed by disk diffusion technique on Muller-Hinton medium, performed according to the Clinical Laboratory Standard Institute (CLSI) guidelines. Results And Discussion: E.coli and Klebsiella were completely(100%) susceptible amikacin and levofloxacin. Thus Levofloxacin, much safer drug was used as first line drug. The alternative drug was amikacin, because of its adverse effects. Second line drug was ciprofloxacin. Cefotaxime can be use for bacteremias. Urinary tract infections were caused by E.coli, Klebsiella. Thus were susceptable to Nitrofurantoin completely. Conclusion: Thus antibiotic sensitivity pattern is intended to provide, clinicians and surgeons, valuable information upon which empiric antimicrobial therapy of infection can be predicted.
Periodontal regeneration is no longer an enigma but now a reality and hence the challenge of periodontal regeneration has come to forefront of research and practice. The aim of the present clinical study was to assess the regenerative potential of porous hydroxyapatite bone graft verses platelet rich plasma, in comparison with open flap debridement in treatment of periodontal intrabony defects. In this study about 30 periodontal intrabony defects in 10 patients, between the age group of 25- 45 were randomly divided into three groups viz., Group-A open flap debridement; group-B bone graft; group-C platelet rich plasma and followed up for a period of 6-months. The clinical and radiographic parameters were assessed in each group at baseline, 3-months and 6-months period. A statistically significant improvement in clinical parameters was observed from baseline to six month treatment period in all the three groups. The observed mean probing pocket depth at 6-months was 5.28 mm for group-A, 4.98 for group-B and 4.36 mm for group-C which was found to be statistically significant [p<0.05] while clinical attachment level were found to be 5.34 mm for group-A, 5.3 mm for group-B and 4.42 mm for group-C, Further, the percentage of radiographic resolution of the defect was found to be 40.8, 66.18 and 46.37% for groups A, B and C respectively. Thus bone grafting was found to be a better treatment modality when compared to open flap debridement and platelet rich plasma alone in treating periodontal intrabony defects.