A COMPARATIVE EVALUATION OF INTERLEUKIN-35 LEVELS IN CHRONIC PERIODONTITIS PATIENTS WITH AND WITHOUT TYPE 2 DIABETES MELLITUS AND ITS RESPONSE TO NONSURGICAL PERIODONTAL THERAPY- A CLINICO- BIOCHEMICAL STUDY

  • Gopiparthi Neeharika Sree
  • Jayasheela M
  • D. S. Mehta
  • vinayaka a m
Cite this:
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G. N. . Sree, J. M, D. S. . Mehta, and vinayaka a m, “A COMPARATIVE EVALUATION OF INTERLEUKIN-35 LEVELS IN CHRONIC PERIODONTITIS PATIENTS WITH AND WITHOUT TYPE 2 DIABETES MELLITUS AND ITS RESPONSE TO NONSURGICAL PERIODONTAL THERAPY- A CLINICO- BIOCHEMICAL STUDY”, ijmhs, vol. 10, no. 10, pp. 1288–1295, Oct. 2020.
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Abstract

Background:Periodontitis is an inflammatory condition of the tooth
supporting structures in which we can discover an imbalance of
cytokines. Interleukin-35 (IL-35) is an anti-inflammatory cytokine that
has been upregulated in chronic periodontitis. Since Diabetes Mellitus
is a systemic condition, where there will be a greater existence of
cytokine imbalance, hence the aim of the present study was to
investigate the role of Gingival Crevicular Fluid (GCF) IL-35 in
chronic periodontitis patients with Type 2 Diabetes Mellitus after
Scaling and Root Planing (SRP).
Materials and Methods: A total of 114 patients with an age range of
30-60 years, were divided into 3 groups: Group I (healthy patients),
Group II (chronic periodontitis), and Group III (chronic periodontitis
with Diabetes Mellitus). Subsequently a thorough Medical & Dental
history was recorded alongside the clinical parameters too and
followed by the collection of GCF samples to perform ELISA analysis
for the detection of IL-35. Latter, the SRP was carried out in Group II
& III with a follow up of 6 weeks. Again at the end of 6 weeks the
clinical parameters were recorded & GCF samples were collected to
perform ELISA analysis for the detection of IL-35.
Results: IL-35 levels were increased in GCF collected from Group II
& III compared to Group I. However, after Non-Surgical Periodontal
Therapy, there was reduction in the IL-35 levels in GCF collected
from Group II & III.
Conclusion: This study clinches that GCF IL-35 levels were higher in
Group II & Group III, which later reduced after SRP, suggesting that
the role of IL-35 in periodontal disease, hence it can be considered as
a Novel Diagnostic Biomarker in the diagnosis of periodontal disease.
KEY WORDS: Biomarker; Chronic periodontitis; Gingival
Crevicular Fluid; Interleukin-35; Type 2 Diabetes Mellitus.

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