Association between Thyroid Autoimmunity and Serum Lipid Levels during Early Pregnancy

Cite this:
[1]
A. K. B. Chandra Sekhar Vanumu, “Association between Thyroid Autoimmunity and Serum Lipid Levels during Early Pregnancy”, ijmhs, vol. 6, no. 4, Aug. 2016.
© 2022 Interactive Protocols
RIGHTS & PERMISSIONS
Article Views
238
Altmetric
1
Citations
-
LEARN ABOUT THESE METRICS
   PDF  

Abstract

Objective: The aim of this study is to find out the prevalence of thyroid autoimmunity during the first trimester of pregnancy and correlated with serum lipid parameters.  Materials and Methods: This study, conducted on 233 pregnant women of age between 18 and 35 years during the first trimester. Serum thyroid stimulating hormone (TSH), free thyroxine (FT4), thyroperoxidase antibodies (TPO-Ab), total cholesterol and triglycerides were analyzed. The significance of prevalence and relative risk of thyroid autoimmunity was calculated by using medcalc easy to use statistical software bvba, version 16.4.3, Ostend. A p-value of ≤ 0.05 was taken as statistically significant.  Results:  The overall prevalence of autoimmunity was 12.4% with the mean of 198.2 IU/ml. The prevalence of subclinical hypothyroid was 30.9%; among them, 25% were thyroid autoantibody-positive pregnant women. The relative risk of autoimmunity was 3.66 times more in subclinical hypothyroid than euthyroid. The mean of TPO-Ab positive was significantly more in subclinical hypothyroid than euthyroid pregnant women with P=0.0003. The mean serum TSH values were significantly higher in TPO-Ab positive than TPO-Ab negative women with P=0.01. The prevalence of autoimmunity was more with TSH>2.5 µIU/L and with moderate levels of cholesterol (154 – 263 mg/dl). Conclusion: Subclinical hypothyroid is more prevalent and frequently remains undiagnosed during early pregnancy. The relative risk of thyroid autoimmunity was increased positively with TSH >2.5 µIU/L and with moderate levels of cholesterol. Thus, all the pregnant women must be screened for TPO-Ab titers, TSH, FT4 and total cholesterol during early pregnancy to predict high- risk pregnancy during early gestation.

KEYWORDS:

 Special Issue

Article Metrics Graph

Chart Graph | Range Graph

Content

Section

Source

License

All paper submissions must carry the following duly signed by all the authors:
“I certify that I have participated sufficiently in the conception and design of this work and the analysis of the data (wherever applicable), as well as the writing of the manuscript, to take public responsibility for it. I believe the manuscript represents valid work. I have reviewed the final version of the manuscript and approve it for publication. Neither has the manuscript nor one with substantially similar content under my authorship been published nor is being considered for publication elsewhere, except as described in an attachment. Furthermore I attest that I shall produce the data upon which the manuscript is based for examination by the editors or their assignees, if requested.”