Association between Thyroid Autoimmunity and Serum Lipid Levels during Early Pregnancy

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A. K. B. Chandra Sekhar Vanumu, “Association between Thyroid Autoimmunity and Serum Lipid Levels during Early Pregnancy”, ijmhs, vol. 6, no. 4, Aug. 2016.
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Abstract

Objective: The aim of this study is to find out the prevalence of thyroid autoimmunity during the first trimester of pregnancy and correlated with serum lipid parameters.  Materials and Methods: This study, conducted on 233 pregnant women of age between 18 and 35 years during the first trimester. Serum thyroid stimulating hormone (TSH), free thyroxine (FT4), thyroperoxidase antibodies (TPO-Ab), total cholesterol and triglycerides were analyzed. The significance of prevalence and relative risk of thyroid autoimmunity was calculated by using medcalc easy to use statistical software bvba, version 16.4.3, Ostend. A p-value of ≤ 0.05 was taken as statistically significant.  Results:  The overall prevalence of autoimmunity was 12.4% with the mean of 198.2 IU/ml. The prevalence of subclinical hypothyroid was 30.9%; among them, 25% were thyroid autoantibody-positive pregnant women. The relative risk of autoimmunity was 3.66 times more in subclinical hypothyroid than euthyroid. The mean of TPO-Ab positive was significantly more in subclinical hypothyroid than euthyroid pregnant women with P=0.0003. The mean serum TSH values were significantly higher in TPO-Ab positive than TPO-Ab negative women with P=0.01. The prevalence of autoimmunity was more with TSH>2.5 µIU/L and with moderate levels of cholesterol (154 – 263 mg/dl). Conclusion: Subclinical hypothyroid is more prevalent and frequently remains undiagnosed during early pregnancy. The relative risk of thyroid autoimmunity was increased positively with TSH >2.5 µIU/L and with moderate levels of cholesterol. Thus, all the pregnant women must be screened for TPO-Ab titers, TSH, FT4 and total cholesterol during early pregnancy to predict high- risk pregnancy during early gestation.

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