TREATMENT OUTCOME AND DETERMINANTS AMONG PATIENTS WITH VISCERAL LEISHMANIASIS IN ARBA MINCH GENERAL HOSPITAL LEISHMANIASIS RESEARCH AND TREATMENT CENTER, GAMO GOFA ZONE, SNNPR, ETHIOPIA

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A. A. Mr. ALEMU TAMISO*, “TREATMENT OUTCOME AND DETERMINANTS AMONG PATIENTS WITH VISCERAL LEISHMANIASIS IN ARBA MINCH GENERAL HOSPITAL LEISHMANIASIS RESEARCH AND TREATMENT CENTER, GAMO GOFA ZONE, SNNPR, ETHIOPIA”, ijmhs, vol. 8, no. 8, pp. 113–131, Aug. 2018.
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Abstract

- Introduction: Visceral Leishmania represents a challenging diagnosis and treatment because the clinical picture of Visceral Leishmaniasis, so that the treatment outcome is compromised with many factors, thus study try to asses real picture of treatment outcome with determinants.

Objective:  To assess treatment outcome and determinant factors among patient with visceral Leishmaniasis in Arba Minch General Hospital Leishmania Research and Treatment Center.

Methods: Institution-based, Cross-sectional, retrospective study was conducted among Leishmaniasis patients in Arba Minch general hospital. Patient charts that have been treated from January 2011-December 2015 were reviewed. A total of 348 charts were selected by Simple Random Sampling technique and included in the study. The data were entered and cleaned using Epi-info version 7.0 and analysis was carried out using SPSS-20 statistical packages. Multi-variate logistic regression analysis was carried out to identify the independent predictors of treatment outcome.

Result: A total of 348 patient's charts were included in the study. The prevalence of poor outcome was found to be 8.6%. The presence of bleeding/Epsitaxis[AOR=5;95% CI:1.3,19.3], tuberculosis[AOR=3.7;95%CI:1.83,6.3],  septic syndrome[AOR=4.3;95% CI: 6.1,32],  and adverse drug side effect[AOR=4.5;95%CI:2.73,13.6] were the independent predictors of treatment outcome.

Conclusion and recommendation: The prevalence of poor treatment outcome among patients with VL in the study area is high. Concomitant infection; bleeding/Epsitaxis, tuberculosis, septic syndrome and adverse side effect were independently associated with poor treatment outcome. The clinical management of VL in co-infected patients is a major challenge that requires new treatment approaches to improve its outcome.

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