COMPARATIVE STUDY OF COMPLETE HAEMOGRAM AND IRON PROFILE FROM CORD BLOOD OF NEW BORN WITH RESPECT TO GESTATION AGE.

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Dr.Madhumita Mondal,Dr.Ayesha Afreen Islam*,Swapan Kumar Sinha,S Saha, “COMPARATIVE STUDY OF COMPLETE HAEMOGRAM AND IRON PROFILE FROM CORD BLOOD OF NEW BORN WITH RESPECT TO GESTATION AGE”., ijmhs, vol. 9, no. 5, pp. 424–430, May 2019.
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Abstract

Infants and toddlers are vulnerable to the effects of anemia due to rapid growth
and development of brain and rest of the body from birth to age three. Preterm
and/or low birth weight infants are more vulnerable. Iron-deficiency anemia
affects neurological development due to reduced myelination of the spinal cord,
as well as a change in myelin composition. To correlate complete serum iron, TIBC and serum ferritin of new born of ?32weeks(wks),
33-36weeks, 37-40weeks and >40weeks gestation age from umbilical cord blood
for early detection of anemia and perinatal managem eonf t complications.
Ninty six new born cord blood was collected of gestation age ? 32wks(10),
33-36wks(12), 37-40wks(60), >40wks(14). Comparison of complete blood count
parameters with respect to gestation age was done in a tertiary care hospital,
Kolkata by ANOVA(one way analysis of variance) test with Graphpad Instat 3
software.
We found significant correlation coefficient for hematocrit(p=0.024), mean
corpuscular volume(p=.0049), platelet count(p=0.0097), red cell distribution
width(p=0.033),serum iron(p=0.0034),serumTIBC(p=0.0482). Anemia is often
first shown by complete blood count (CBC). Sufficiently low hemoglobin
(HGB) by definition makes the diagnosis of anemia, and low hematocrit
(HCT) value is also characteristic of anemia. Biochemical tests usually
done are serum ferritin, serum iron level, total iron binding capacity (TIBC).
Currently, there is no clear recommendation of iron supplementation to the
new born with decreased iron content other than exclusive breast feeding
which is compulsory to all new born. As it is an easy, early and non-invasive
procedure of estimation of fetal iron deficiency, it may be
recommended in health care programmes for early detection and treatment of
iron deficiency before the development of actual anemia.

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References

1. Bridges KR, Pearson HA. Anemias and other red cell disorders. New York NY Mc Graw Hill;2008:99-100. 2. Maguire JL, de Veber G, Parkin PC. Assotiation between iron deficiency anemia & stroke in young children; Pediatric 2007;120:1053-7. 3. Kavadas FD. Iron deficiency anemia is associated with cerebral sino venous thrombosis:a case series. Pediatrics 2008;121:5146-7. 4. Peirano PD, Algarin CR , Garrido MI, Lozoft B, Iron deficiency anemia in infancy is associated with altered temporal organization of sleep states in childhood Ped Res 2007;62:715-9. 5. Mc Queen R Pediatric & Geriatric hematology.In:Rodak BF, Fritsma GA, Doig K, editors.Hematology:clinical principles and applications,3rd edition.St. Louis, Mo:Elsevier;2007:526-40. 6. Sivkumar S, Bhat BV et al. Effect of Pregnancy Induced Hypertension on Mothers and their Babies. Indian Journal of Pediatrics.2007 July; vol 74. 7. Elizabeth KE, Krishnan V, Vijaykumar T. Umbilical Cord blood nutrients in low birth weight babies in relation to birth weight and gestational age. Indian J Med Res 2008;128:128-133. 8. Siddappa AM, Rao R, Long JD et al. The assessment of new born iron stores at birth: a review of literature and standards for ferritin concentrations. Neonatology 2007;92:73-82. 9 Shao J, Lou J, Rao R, et al. Maternal serum ferritin concentration is positively associated with newborn iron stores in women with low ferritin status in late pregnancy. J Nutr 2012;142:2004-9. 10. Lorenz L, Peter A, Poets CF, Franz AR. A review of cord blood concentrations of iron status parameters to define reference ranges for preterm infants. Neonatology 2013;104:194-202.

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References

1. Bridges KR, Pearson HA. Anemias and other red cell disorders. New York NY Mc Graw Hill;2008:99-100.
2. Maguire JL, de Veber G, Parkin PC. Assotiation between iron deficiency anemia & stroke in young children; Pediatric 2007;120:1053-7.
3. Kavadas FD. Iron deficiency anemia is associated with cerebral sino venous thrombosis:a case series. Pediatrics 2008;121:5146-7.
4. Peirano PD, Algarin CR , Garrido MI, Lozoft B, Iron deficiency anemia in infancy is associated with altered temporal organization of sleep states in childhood Ped Res 2007;62:715-9.
5. Mc Queen R Pediatric & Geriatric hematology.In:Rodak BF, Fritsma GA, Doig K, editors.Hematology:clinical principles and applications,3rd edition.St. Louis, Mo:Elsevier;2007:526-40.
6. Sivkumar S, Bhat BV et al. Effect of Pregnancy Induced Hypertension on Mothers and their Babies. Indian Journal of Pediatrics.2007 July; vol 74.
7. Elizabeth KE, Krishnan V, Vijaykumar T. Umbilical Cord blood nutrients in low birth weight babies in relation to birth weight and gestational age. Indian J Med Res 2008;128:128-133.
8. Siddappa AM, Rao R, Long JD et al. The assessment of new born iron stores at birth: a review of literature and standards for ferritin concentrations. Neonatology 2007;92:73-82.
9 Shao J, Lou J, Rao R, et al. Maternal serum ferritin concentration is positively associated with newborn iron stores in women with low ferritin status in late pregnancy. J Nutr 2012;142:2004-9.
10. Lorenz L, Peter A, Poets CF, Franz AR. A review of cord blood concentrations of iron status parameters
to define reference ranges for preterm infants. Neonatology 2013;104:194-202.

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