Impact of Persistent Hyperglycemia on fractional Excretion of Potassium.

Dr Rajesh Kumar Sinha*, Dr Kumar Ashutosh

Impact of Persistent Hyperglycemia on fractional Excretion of Potassium.

Dr Rajesh Kumar Sinha*, Dr Kumar Ashutosh

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Dr Rajesh Kumar Sinha*, Dr Kumar Ashutosh, “Impact of Persistent Hyperglycemia on fractional Excretion of Potassium”., ijmhs, vol. 10, no. 04, pp. 934–937, Apr. 2020.

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Abstract

Background-Our daily recommended use of potassium is 3.5 gm/day 1. Potassium
is a positive electrically charged particle called anions that takes part in carrying
the nerve impulses. In healthy person safe level of potassium varies between 3.7 and
5.2 milliequivqnt per liter (mEq/L):8 Till the kidney functions are not compromised
physiological level is maintained Even in low or high intake of potassium. Complication
of hyperkalemia is slow heart beat and weak pulse but in case of severe hyperkalemia
there may be stoppage of cardiac impulse.10
In poorly controlled diabetes mellitus II more breakdown of adipose tissue due to lack
of insulin cause more ketone production and ketoacidois. This ketoacidosis along with
hyperglycemia tends to pull the potassium out the cell. The combination of shift out
of potassium from the cell and diminished potassium excretion by the kidney leads to
hyperkalemia in case of Diabetes Mellitus type II.
Material and method 111 subjects having age between 30 to 55 both diabetic and
non diabetic were selected. 5 ml blood was collected by vein puncture and fasting
blood sugar, serum potassium level and HbA1c was estimated in the department of
physiology .Fractional excretion of potassium will be calculated by the formula given
below. Fractional excretion of potassium was calculated by the formula given below:
FEK = ( Urine K/Serum K)/ (Urine Cr /Serum Cr) X 100 11
Result - Serum Creatinine was within normal limit <1mg/dl in Group A and B Where
HbA1C range was 5-6.5. Even in Group C HbA1c range 6.6-7.9 serum creatinine was
normal. Level of serum creatinine rises to 1.3 in group D where the HbA1C was
>8%Mean excretion of potassium in urine was 36 mg/dl and 38mg/dl in HbA1C
range between 5-5.6 % and 5.7-6.5 %respectively. in cases where HbA1C was > 8%
excretion of potassium in urine was only 39mg/dl though it was increased a little
42mg/dl when HbA1C range was 6.5-7.9%
FEK was 8.1 till the HbA1C remains below 6.5% . FEK Gradually decreased to 7.5%
in HbA1C range 6.6-6.9% and even more lower 6.8% when HbA1C was > 8%.
Discussion -In Persistent poor control of blood sugar level kidney fails to handle the
potassium excretion and subsequently Serum potassium level begins to rise. kidney
tries to maintain the serum potassium level not only by increasing the excretory rate
of potassium .when the there was poor glycemic control ,i.e HbA1c was more the 8 %
in spite of having more excretion of potassium.
Conclusion- High level of potassium observed in case patients of diabetes mellitus.
Regular check up of micro albumin in the urine ,Keeping the HB1Ac level below 7
,by cutting down the intake of potassium in diet, progress of kidney disease in case of
Diabetes mellitus can be minimized.
Key words: HbA1c–glycated hemoglobin.FEK Fractional excretion of potassium–
FBS–Fasting Blood sugar

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[1]

Dr Rajesh Kumar Sinha*, Dr Kumar Ashutosh, “Impact of Persistent Hyperglycemia on fractional Excretion of Potassium”., ijmhs, vol. 10, no. 04, pp. 934–937, Apr. 2020.

Issue Vol. 10 No. 04 (2020): Innovative Journal of Medical and Health Science
Section Research Articles

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Innovative Journal of Medical and Health Sciences

Impact of Persistent Hyperglycemia on fractional Excretion of Potassium.

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