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  3. Vol. 10 No. 06 (2020): Innovative Journal of Medical and Health Science
  4. Research Articles

Evidence level for effectiveness of glucagon-like peptide-1 receptor agonists respectively sodium glucose co-transporter-2 inhibitors for mitochondrial diabetes is low

  • Josef Finsterer, MD, PhD*, Marlies Frank, MD
  • Josef Finsterer, MD, PhD*, Marlies Frank, MD
     Krankenanstalt Rudolfstiftung, Messerli Institute, Austria

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Josef Finsterer, MD, PhD*, Marlies Frank, MD, “Evidence level for effectiveness of glucagon-like peptide-1 receptor agonists respectively sodium glucose co-transporter-2 inhibitors for mitochondrial diabetes is low”, ijmhs, vol. 10, no. 06, pp. 959–960, Jun. 2020.
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Abstract

We read with interest the article by Yeung et al. about
three patients with a multisystem mitochondrial disorder
(MID) due to the variant m.3243A>G with heteroplasmy
rates (HPRs) of 60% (patient-1), 30% (patient-2), and 10%
(patient-3) in blood lymphocytes respectively who were successfully
treated for mitochondrial diabetes (MTDM) with
the glucagon-like peptide-1 receptor agonist (GLP-1 RA)
semaglutide (patient-1) respectively the sodium glucose cotransporter-
2 inhibitor (SGLT-2i) empaglifozin (patient-2,
patient-3) [1]. The authors concluded from this case series
that providers should be encouraged to prioritise GLP-1 RA
respectively SGLT-2i for the treatment of MTDM [1]. We
have the following comments and concerns.

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  • [1]
    Josef Finsterer, MD, PhD*, Marlies Frank, MD, “Evidence level for effectiveness of glucagon-like peptide-1 receptor agonists respectively sodium glucose co-transporter-2 inhibitors for mitochondrial diabetes is low”, ijmhs, vol. 10, no. 06, pp. 959–960, Jun. 2020.
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  • Issue Vol. 10 No. 06 (2020): Innovative Journal of Medical and Health Science
  • Section Research Articles

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