Metabolic Syndrome & Carcinoma Prostate: Association Of Abdominal Obesity, Insulin Resistance, Hyperlipidemia And Diabetes Mellitus In Carcinoma Prostate

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D. K. M. S. S. R. R. . Felix Cardoza, “Metabolic Syndrome & Carcinoma Prostate: Association Of Abdominal Obesity, Insulin Resistance, Hyperlipidemia And Diabetes Mellitus In Carcinoma Prostate”, ijmhs, vol. 10, no. 12, pp. 1411–1414, Dec. 2020.
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Abstract

Objectives : To study the effect of central obesity (waist hip ratio WHR ? 0.9) and biochemical parameters associated with central obesity (hyperinsulinemia, dyslipidemia, diabetes mellitus) on Gleason grading in patients of prostate cancer presenting at advanced stages

Materials and Methods : A comparative study was conducted among 68 patients having clinical stages III and IV prostate cancer at Government Medical College, Kozhikode between Aug 2011 and Aug 2012. Gleason grading on core biopsy samples was done and patients were divided in two groups-group1, Gleason score ?7; group 2, Gleason score <7. WHR along with serum levels of prostate-specific antigen (PSA), testosterone, insulin, and lipid profile were done in each patient. Fasting and post prandial blood sugar levels were done in diabetic patients

Results : Two groups are similar in Age (66.34 years); range (53-80 years). Group 1 men had statistically higher mean WHR (1.06 vs 0.90), higher mean cholesterol (205 vs 180 mg/dL), higher mean low-density lipoprotein (LDL) (160 vs 110 mg/dL), than men in group 2. Serum levels of VLDL, HDL, Insulin and testosterone did not show statistically significant differences between two groups. No association could be linked between diabetes mellitus and its duration in patients with advanced stage prostate cancer.

Conclusions : This pilot study involving small number of patients indicates that central obesity and dyslipidemia could be associated with high-grade prostate cancer.

Keywords: Central obesity, Hyperinsulinemia, Dyslipidemia, Diabetes mellitus, Carcinoma Prostate

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