Pattern of left ventricular abnormalities in people with pre-diabetes

Dr Mohd abass  Bhat; Dr Nazir  A Pala; Dr Syed  Manzoor Anderabi; Dr Shahnawaz  Hassan

doi:10.15520/ijmhs.v11i05.3284

Pattern of left ventricular abnormalities in people with pre-diabetes

Dr Mohd abass Bhat

Dr Nazir A Pala

Dr Syed Manzoor Anderabi

Dr Shahnawaz Hassan

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D. M. abass . Bhat, D. N. . A Pala, D. S. . Manzoor Anderabi, and D. S. . Hassan, “Pattern of left ventricular abnormalities in people with pre-diabetes”, ijmhs, vol. 11, no. 03 (May - June), pp. 1642–1649, May 2021.

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Abstract

Purpose of study: Left ventricular dysfunction in people with diabetes mellitus has been demonstrated by various studies in past. However, there is little and conflicting data with regard to Left Ventricular abnormalities in people with Pre-diabetes. In view of Scarcity of data, we designed a study to investigate the early abnormalities in left ventricular function in normotensive people with prediabetes compared to healthy controls, using Doppler Echocardiography

Methods: Prospective hospital based case-control study, conducted at a tertiary care hospital in north India. 100 people with prediabetes without known cardiovascular disease, with equal number of matched controls were enrolled in the study. A detailed medical history, clinical examination, biochemical profile and echocardiographic studies were performed in all study subjects.

Results: Early diastolic wave (E;0.693±0.092m/s), Early diastolic wave (E)/late diastolic wave (A) ratio (E/A;0.887±0.095), left ventricular end systolic diameter (LVESD; 24.78±1.640mm) were significantly lower in people with prediabetes, whereas isovolumetric relaxation time (IVRT;87.45±8.148ms), sphericity index (0.595±0.028) and left atrial diameter (35.50±1.693mm) were significantly higher in people with pre-diabetes compared to matched controls. However, no correlation was observed with regard to anthropometric variables (body-mass index (BMI), waist circumference) and lipid profile

Conclusion: Prediabetes is associated with subclinical left Ventricular systolic and diastolic abnormalities as evaluated on conventional and pulse-wave echocardiography.

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Issue Vol. 11 No. 03 (May - June) (2021): Innovative Journal of Medical and Health Science
Section Research Articles

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Pattern of left ventricular abnormalities in people with pre-diabetes

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