A CLINICAL EVALUATION OF PROPOFOL IN SHORT SURGICAL PROCEDURES AND COMPARISON WITH THIOPENTONE SODIUM AS INDUCTION AGENT IN IMMUNOCOMPROMISED HIV PATIENTS

  • Lalit Kumar Garg
  • Anjana
  • Deepak Berry
  • Tanveer Singh Kundra
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Lalit Kumar Garg, Anjana, Deepak Berry, and Tanveer Singh Kundra, “A CLINICAL EVALUATION OF PROPOFOL IN SHORT SURGICAL PROCEDURES AND COMPARISON WITH THIOPENTONE SODIUM AS INDUCTION AGENT IN IMMUNOCOMPROMISED HIV PATIENTS”, ijmhs, vol. 11, no. 03 (May - June), pp. 1675–1681, May 2021.
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Abstract

BACKGROUND: Numerous attempts have been made in the past for the selection of an ideal intravenous anaesthetic agent for outpatient short surgical   procedures in immunocompromised patients. The present study compared the effect of two drugs namely propofol and thiopentone sodium as an induction agent in short surgical procedures in immunocompromised HIV patients.

Materials and Methods: This was a randomized study evaluating  two drugs- propofol and thiopentone sodium in short surgical procedures. It was carried out on 100 immunocompromised HIV patients in age group of 18-45 yrs of ASA grade 1/2 undergoing short surgical procedures .

These patients were randomly divided into 2 groups 1 and 2 which were further subdivided into 1a and 1b , 2a and 2b respectively, each consisiting of 25 pts.

Group 1a and 2 a were given inj pentazocine 30mg and inj promethazine 25mg

Group 1b and 2b  were administered 2 ml of saline .

Group  1a and 1b received inj propofol 1%i/v dose 2.5mg/kg wt and group 2a and 2b were given inj thiopentone 2.5% i/v at dose of 5mg/kg wt.

RESULT: Propofol showed a greater decrease in diastolic and systolic BP at induction, respiratory rate with more incidence of apnea.

CONCLUSION: Propofol produces rapid, pleasant and safe anaesthesia, with smooth  recovery while thiopentone is associated with poor psychomotor recovery in immunocompromised HIV patients.

KEY WORDS: Propofol, Thiopentone sodium, Short surgical procedures, immunocompromised, HIV

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