IMPACT OF STRESS ON HISTOLOGY AND BIOCHEMICAL PARAMETERS OF LIVER AND KIDNEY OF MICE

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R. K. *, S. K. M. A. A. K. A. Nath, Kapil Lawrence , J.K. Singh, “IMPACT OF STRESS ON HISTOLOGY AND BIOCHEMICAL PARAMETERS OF LIVER AND KIDNEY OF MICE”, ijmhs, vol. 2, no. 4, Oct. 2013.
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Abstract

Epinephrine is a hormone and neurotransmitter. When produced in the body it increases heart rate, contracts blood vessels and dilates air passages and participates in the "fight or flight" response of the sympathetic nervous system. During stress concentration of epinephrine were increased many times. In present study epinephrine were administered to mice @ 200nl/k.g.bw to induce stress in animal, which were dissected after 2 and 4 weeks. SGOT and Urea level in serum were increased in epinephrine administered group. Liver and kidney tissue were fixed for light microscopy and serum were collected for SGOT and urea assay. While after administration of epinephrine frequent vacuolisation were observed. Elongated nucleus was also observed in hepatic cells. Degenerated hepatic vein were also observed. While in kidney dilated bowmen’s capsule were observed. Frequent vacuolization were also observed in cortex region. Endothelial cells of PCT were observed in degenerated condition. Thus it is concluded from entire study that stress causes degeneration in hepatic cells, central vein, glomerulus, bowmens capsule, PCT and DCT which finally leading to both hepato-toxicity and nephro-toxicity.

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