CLINICOPATHOLOGICAL STUDY OF AN IRAQI PATIENTS GROUP SUSPECTED TO HAVE COELIAC DIASEASE

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M. T. O. S. A. A.-N. M. H. F. Balsam I Taha, “CLINICOPATHOLOGICAL STUDY OF AN IRAQI PATIENTS GROUP SUSPECTED TO HAVE COELIAC DIASEASE”, ijmhs, vol. 2, no. 5, Oct. 2013.
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Abstract

As the diagnosis of CD is more than expected among children and adults in Iraq, this study was carried out to describe the clinical features, histological and serological correlations in an Iraqi patients group consisted of adults and children suspected to have CD, and to correlate the serological results with the intensity of mucosal damage. 314 patients (142 male, 172 female, mean age, 15 years, range, 1–72) were recruited in the study. All were suspected on clinical basis to have coeliac disease. Endoscopy and duodenal biopsy in addition to serological assessment were done. The duodenal biopsies interpreted histologically according to modified Marsh criteria and the sera were tested for antigliadin antibody (AGA), endomysium antibody (EMA) and anti tissue transglutaminase antibody (tTG ). It has been shown that histopathology still constitutes the golden standard test for ultimate diagnosis of CD according to Marsh criteria. Detection of the presence of EMA and tTG antibodies were diagnostic for the disease (PPV was 100%), while AGA is of less important since its sensitivity, was 77.6%. CD may be a prevalent life-long gastrointestinal diseases in Iraq. The study showed that the clinical features of coeliac disease have changed, symptoms are often minor and the disease can even be clinically silent. Histopathology was the golden standard test for diagnosis of the disease. Detecting the presence of serum antibodies was almost diagnostic for clinically suspected coeliac disease in children and adults especially EMA and tTG.

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