Introduction Helicobacter pylori infection is now recognised as a worldwide problem. It is the most common cause of chronic gastritis, and is strongly linked to peptic ulcer disease and gastric cancer.
Material And Methods Blood and antral biopsy specimens from 70 dyspeptic patients and 10 control subjects were collected. All the specimens were processed within 2-3 hours. Rapid urease test, Primary smear, Culture was done on freshly prepared brain-heart infusion agar supplemented with 7% horse blood, vancomycin and amphotericin B. Plates were incubated at 37°C under microaerophilic conditions. Histology was done using Heamatoxylin & Eosin staining and Giminez staining. Serology was also performed using a commercial kit - Novum Helicobacter pylori IgG and IgA ELISA manufactured in Germany.
Results The age of the study population of 70 patients ranged from 18-70 years and of 10 controls between 22-45 year. There were 54.16% males and 63.63% females. In the present study, there were 03 patients with endoscopically evident gastritis and duodenal ulcer with incidence rate of H.pylori i.e 66.6%. Maximum cases had gastritis(72.8%) followed by 15.7% cases of normal mucosa . Forty (57.1%)were found to have H. pylori in their antral biopsies by histology.
Conclusions H.pylori infection is acquired early in life in the Indian population The H.pylori infection has a high morbidity rate, but a low mortality rate and is curable with antibiotic therapy
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