EFFECTIVENESS OF GLYCYRRHIZINIC ACID AND AN IMMUNOSTIMULANT TO TREAT GENITAL WARTS IN THE PEDIATRIC PATIENT POPULATION

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E. M. R. F. P. C. R. R. A. Y. R. Zelenkova Hana, “EFFECTIVENESS OF GLYCYRRHIZINIC ACID AND AN IMMUNOSTIMULANT TO TREAT GENITAL WARTS IN THE PEDIATRIC PATIENT POPULATION”, ijmhs, vol. 3, no. 3, Oct. 2013.
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Abstract

Background: Anogenital warts are proliferations of skin and mucosa caused by the Human Papilloma Virus (HPV) infection which is becoming increasingly more common among the pediatric patient population. Objective: Evaluate the effectiveness of combining glycyrrhizinic acid (Glizigen) with a food supplement (VIUSID) to boost the immune system when treating external anogenital warts in pediatric patients. Method: A longitudinal, randomized, double-blind, controlled, phase IV clinical trial was carried out on 76 patients of both genders aged between 6 and 18, who had been diagnosed with anogenital warts. The treatment consisted in the topical application of glycyrrhizinic acid together with the food supplement that was taken orally, three times a day for twelve weeks, with fortnightly check-ups, to evaluate the effectiveness of this combination according to the patient's response to the treatment and to identify any adverse reactions experienced. The relationship between the time taken for the lesions to disappear and the patient's response to the treatment along with the reduction in the number of lesions and their clinical presentation were all taken into account. Results: The lesions of 68.4% of the patients (26 individuals) disappeared altogether and for the other 28.9% (11 patients) the lesions decreased by more than 75%. Out of the 26 patients whose lesions disappeared completely, this happened in the first 4 weeks for 61.5% and between the 5th and the 8th week for the other 38.5%. The papillomatous lesions responded better to the treatment and no adverse reactions were observed during the clinical trial: Conclusion: The combination of glycyrrhizinic acid and the immunostimulant food supplement is a safe and effective alternative to treat anogenital warts affecting the pediatric patient population.

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