PROTECTIVE EFFECTS OF SOLANUM LYCOPERSICUM FRUIT EXTRACT ON CYCLOPHOSPHAMIDE INDUCED MICRONUCLEI IN BONE MARROW CELLS OF MICE.

Cite this:
[1]
K. R. devi Sri Vani, Minny Jael .P, “PROTECTIVE EFFECTS OF SOLANUM LYCOPERSICUM FRUIT EXTRACT ON CYCLOPHOSPHAMIDE INDUCED MICRONUCLEI IN BONE MARROW CELLS OF MICE”., ijmhs, vol. 4, no. 2, Apr. 2014.
© 2022 Interactive Protocols
RIGHTS & PERMISSIONS
Article Views
540
Altmetric
1
Citations
-
LEARN ABOUT THESE METRICS
   PDF  

Abstract

In the present investigations the antimutagenic effect of solanum lycopersicum fruit extract has been evaluated against cyclophosphamide (CP) induced micronuclei in bone marrow cells of mice. Single i.p administration of solanum lycopersicum fruit extract at various test doses namely 250, 500 and 1000 mg/kg b.w have given protection when 24hr prior administration of single doses of cyclophosphamide (50mg/kg b.w). A dose dependent inhibition of micronuclei was observed when animals were primed with solanum lycopersicum fruit extract. Thus the results indicate preventive effects of solanum lycopersicum fruit extract against cyclophosphamide induced genotoxicity in bone marrow cells of mice. Therefore the data showed SL fruit extract is a safer dietary component in cancer chemo preventive strategy.

KEYWORDS:

 Special Issue

Article Metrics Graph

Chart Graph | Range Graph

Content

Section

Source

License

All paper submissions must carry the following duly signed by all the authors:
“I certify that I have participated sufficiently in the conception and design of this work and the analysis of the data (wherever applicable), as well as the writing of the manuscript, to take public responsibility for it. I believe the manuscript represents valid work. I have reviewed the final version of the manuscript and approve it for publication. Neither has the manuscript nor one with substantially similar content under my authorship been published nor is being considered for publication elsewhere, except as described in an attachment. Furthermore I attest that I shall produce the data upon which the manuscript is based for examination by the editors or their assignees, if requested.”