Shaiji.P.S, Sobha Kumar, K.C.Usha
Background -Most of thrombocytopenic episodes in an NICU is reported as mild and self limiting,but a few of them progress to higher degrees. This study aims to identify neonates who develop moderate to severe thrombocytopenia in Neonatal Intensive care Unit of a tertiary hospital.
Objective - To identify the factors associated with thrombocytopenia of moderate to severe degrees in a level III NICU compared to infants with mild thrombocytopenia
Settings and Design: A Case control study in newborns admitted in Neonatal Intensive Care Unit under Division of Neonatology at Medical college, Thiruvananthapuram between February to June 2009 .
Methods and Material - Cases(n=92) were newborns with documented thrombocytopenia .71 cases had moderate thrombocytopenia (platelet count less than 1X105 /mm3)Â and 21 had severe thrombocytopenia(platelet count less than .5X105/mm3). Controls(n=149) were newborns admitted at the same period with mild thrombocytopenia (<1.5X105/mm3).Presence of associated factors namely sepsis, birth asphyxia, necrotising enterocolitis, maternal diabetes mellitus ,maternal hypertension were compared.
Statistical analysis used - Univariate analysis was done with Chi Square test for comparison of qualitative data of risk factors.Risk estimate was Odds Ratio with 95% Confidence Interval.
Results - Of the 1038 admissions in NICU,240 babies(23.12%)developed thrombocytopenia but only 92 were either moderate or severe(8.86% of all admissions and 38.33% of of all thrombocytopenic newborns). Out of 240 thrombocytopenic neonates 71 cases(29.5%)had moderate decrease and 21(8.75%) had severe. 71 neonates received platelet transfusions out of which 42 were mutitransfused.Major riskfactors identified were Sepsis, Necrotising Enterocolitis ,Hypoxia and maternal thrombocytopenia.
Conclusions - Even though a quarter of newborns admitted at NICU develop thrombocytopenia,only 8%progress to moderate or severe thrombocytopenia.Major factors associated with higher degrees of thrombocytopenia are sepsis, necrotising enterocolitis, and hypoxia in utero.Most of the neonates recover without bleeding.