Background: In developing countries chemotherapy and their administration cost is the major issue which is addressed by introducing chemotherapy infusion pumps, started for the first time in oncology day care at Aga khan university hospital Karachi Pakistan in the year 2012.Chemotherapy which was studied for this purpose was 5-Florouracil given through 46 or 96 hours infusion pumps implemented in the following regimes:
FOLFOX: Folinic Acid+5-Florouracil+Oxaliplatin
FOLFIRI: Folinic Acid+ 5-Florouracil+Irinotecan
FOLFIRINOX: Folinic Acid +5-Florouracil+Irinotecan+Oxaliplatin
DCF: Docetaxel+Cisplatin+5-Florouracil
The above mentioned Chemotherapy regimens are mostly used in gastrointestinal cancers such as colorectal, gastric and pancreatic cancers.
Methodology: A comparative study is done on cost difference and patients satisfaction, by developing survey forms and 3 months data of patients was gathered who were admitted for three to four days in ward to receive chemotherapy and compared with those who were admitted in oncology day care for six to eight hours for the same treatment.
Results: Results turned up as remarkable cost reduction, increased convenience, more compliance and hence overall great patient’s satisfaction.
Conclusion: It is concluded that chemotherapy administration in oncology day care for gastrointestinal cancers after introduction of elastomeric portable infusion pumps for 46 or 96 hours of 5-FU not only increased patient’s satisfaction with less financial burden but also enabled patients to perform normal routine activities of life.Throughout the history of warfare, military leaders have recognized the potentially devastating consequences of ailing armies. Outbreaks of disease among the ranks have contributed to the collapse of empires and the falls of dynasties. Even today, we are just one mutation away from catastrophic consequences that would literally reshape the world as we know it. While it is true that the World Wars underscore the capacity of armed conflict among world powers to spread disease on a global scale, they also highlight the medical advances that often accompany modern warfare. Herein, we reflect upon the role of the World Wars in establishing a trajectory for modern medicine and posit an organizational role for our armed forces as a platform of cooperation in global public health.
Aims and Objectives To study the cardiac profile of organophosphate compound poisoning.
Method About 100 cases of organophosphate poisoning admitted over a period of 1 year in SS Institute of Medical Sciences were studied. ECG was carried out daily on all patients during their stay. Chest x ray and estimation of serum electrolytes were done routinely on admission. Cardiac enzyme estimation was done if ECG showed significant changes along with echocardiography. As there was no method available for estimation of organophosphate compound, blood pseudo cholinesterase levels were estimated.
Results: Males were predominant (86%) with 26-35 year age group being more common. Majority of them did not have ECG (57%) changes, with 4% had pulmonary oedema and 5% hypotension, 4% hypertension and out of 7 patients who underwent 2D Echo , 2 of them had Acute Myocardial Infarction Cardiac changes on ECG were seen more commonly among patients having very low pseudocholine esterase levels (60.9%). This association was found to be statistically significant (p<0.05).