Innovative Journal of Medical and Health Sciences

Candida infection is common and fatal in premature infants especially when it is persistent candidemia. It is very important to treat the primary source/focus of candida infection. Sometimes it becomes hard in clinical practice to do so, which causes a lot of morbidity and mortality to infants with this condition. The author’s report a former 22-weeker girl who developed the thrombocytopenia and increased oxygen demand during the NICU stay and blood was cultured which came positive for C. parasilopsis. Culture remained positive for C. parasilopsis in spite of giving appropriate antifungal due to infected thrombus in Inferior Vena Cava (IVC). We had to consider fragility and morbidities of the former 22-weeker into account while Managing the infected thrombus. The baby survived even with maximum number of reported days persistent candidemia by achieving negative blood culture after some time.

Solitary fibrous tumor of kidney is a rare mesenchymal cell tumor. It is an unusual spindle cell neoplasm identical to hemangiopericytoma. About 50 cases have been reported in the available literature so far. We present a case report of a 60 year old female who presented with urinary incontinence and swelling of lower limbs since 2 months.The CT scan showed a well defined, large 22x16x14.5cm sized, lobulated mass arising from upper pole of left kidney.She was operated upon and the mass excised. Histology and immunohistochemistry helped in arriving at a definite diagnosis of a solitary fibrous tumour.  It is being reported due to its rarity of occurrence in the kidney.

Introduction: The last erupted teeth are third molar teeth and eruption times, eruption levels and positions of third molar teeth observed differences. Third molars caused various problems such as caries and distal root resorption of neighboring second molars and crowding of anterior teeth.

Material and method: 770 children ages between 8-13 have panoramic radiographies

evaluated. The classification determined by Demirjian was modified and used in our study to determine the existence and development levels of third molars.

The radiographies were examined by two researchers. Mann-Whitney U and Wilcoxon tests were carried out in order to determine the relationship between gender and age. The relationship of each Demirijian development period with age was calculated. McNemar test was used in order to determine the developmental period distribution differences between the lower and upper third molars.

Results: No statistically significant difference was observed in terms of gender between the patients who have none of the third molars in radiographies and patients who have all third molars in radiographies. It has been observed that there is no statistically significant difference between males and females according to mineralization stages.

Conclusion: It is important to know the development periods of third molars which are important for the pedodontic treatment planning in mixed dentition period.

Angiotensin II (ANGII) is a systemic vasoconstrictor and body fluid regulator. Virtually all released ANGII binds to AT1 receptors, which stimulates cell signaling pathways in various cell types. In kidneys, ANGII enhances arachidonic acid release by increasing the activity of phospholipase enzymesand cyclooxygenase-2 (COX-2), leading to an elevation in prostaglandinlevels where prostaglandin E2 (PGE2) is predominately generated. Male Sprague Dawley rats (200 – 300g) were acutely injected for four hours by vehicle or ANGII (7ng/kg/min, IV). Blood pressure was elevated significantly during ANGII infusion from (109.82 ± 0.085mmHg) to (129.36 ± 0.1mmHg). Urine flow(8.98 ± 0.23μl/min), glomerular filtration rate (1.93 ± 0.18ml/min/gm), and renal blood flow(1.75 ± 0.064ml/min) were decreased in comparison with control(14.03 ± 0.26μl/min), (2.71 ± 0.075ml/min) and (3.8 ± 0.14ml/min/gm) respectively. Through renal microdialysis, we found that PGE2 levels were significantly induced by ANGII treatment (358.27 ± 35.3pg/ml)when compared to control(234.39 ± 11.72pg/ml).Also, acute ANGII infusion augmented the present oxidative stress in renal tissues. Superoxide and peroxynitrite levels were increased by two fold during ANGII treatment when evaluated by EPR using CMH and CPH as spin traps.In the current study, we found that local effects of acute ANGII infusion stimulate PGE2 and free reactive species, which produce a disruption in normal renal hemodynamic function. In summary, the present study demonstrates a potential mechanism by which acute elevations in ANGII promotes hypertension induced end organ kidney damage.