Evidenced-based and national context orientated Guidelines help clinicians translate best evidence into best practice. A well-calipered guideline improves quality by reducing variations in healthcare delivery. Clinical Guidelines remarkably contributing to Improving diagnostic accuracy, enhancing effective therapy, and restricting ineffective – or potentially non-effective – interventions. Clinical guidelines methodology seems to be poorly defined and clearly varies at different organizations. One of the gaps needs to be closed under national clinical guidelines is to generate and develop a quality-driven, evidence-based through utilizing an efficient and rigors methodology for action and setting up ready recommendations with multi-disciplinary applicability. The Process of development, that permit moving from conception to completion in a well-defined period of time, always emphasizes a logical sequence of key action statements supported by amplifying text, evidence profiles, as well as a recommendation which link action to evidence.