Innovative Journal of Medical and Health Sciences

Introduction: Pain in the immediate postoperative period is less after laparoscopic surgery  than conventional  surgical techniques. Ropivacaine is often in favored over Bupivacaine to avoid toxicity. Levo-bupivacaine a newer version of bupivacaine is said to be safer than Ropivacaine. We have evaluated the pain relief provided by Ropivacaine and Levo-bupivacaine instilled intra-abdominally during laparoscopic surgery for acute appendicitis.

Methods and material: In a randomized placebo controlled study conducted on 90 patients in private medical institute over a period of year, a  patient control analgesia (PCA) total amount of morphine utilized to attain pain scores of 0-1 was measured in placebo, Ropivacaine and Levo-bupivacanie group  using visual analog score (VAS). Data was analyzed using analysis of variance and tests of statistical significance were employed.   

Results:  Significant difference was not observed between the Ropivacaine and Levo-bupivacaine groups with similar utilization of morphine for both drugs. Whereas significant difference was noted between placebo and local anaesthetics. 

Conclusions: There appear to be no difference between Ropivacaine and Levo-bupivacaine in terms of pain relief. Pre-emptive instillation of local anaesthetic for laparoscopic surgery is beneficial for post-operative pain relief.

Introduction: Pain in the immediate postoperative period is less after laparoscopic surgery  than conventional  surgical techniques. Ropivacaine is often in favored over Bupivacaine to avoid toxicity. Levo-bupivacaine a newer version of bupivacaine is said to be safer than Ropivacaine. We have evaluated the pain relief provided by Ropivacaine and Levo-bupivacaine instilled intra-abdominally during laparoscopic surgery for acute appendicitis.

Methods and material: In a randomized placebo controlled study conducted on 90 patients in private medical institute over a period of year, a  patient control analgesia (PCA) total amount of morphine utilized to attain pain scores of 0-1 was measured in placebo, Ropivacaine and Levo-bupivacanie group  using visual analog score (VAS). Data was analyzed using analysis of variance and tests of statistical significance were employed.   

Results:  Significant difference was not observed between the Ropivacaine and Levo-bupivacaine groups with similar utilization of morphine for both drugs. Whereas significant difference was noted between placebo and local anaesthetics. 

Conclusions: There appear to be no difference between Ropivacaine and Levo-bupivacaine in terms of pain relief. Pre-emptive instillation of local anaesthetic for laparoscopic surgery is beneficial for post-operative pain relief.

Introduction: Pain in the immediate postoperative period is less after laparoscopic surgery  than conventional  surgical techniques. Ropivacaine is often in favored over Bupivacaine to avoid toxicity. Levo-bupivacaine a newer version of bupivacaine is said to be safer than Ropivacaine. We have evaluated the pain relief provided by Ropivacaine and Levo-bupivacaine instilled intra-abdominally during laparoscopic surgery for acute appendicitis.

Methods and material: In a randomized placebo controlled study conducted on 90 patients in private medical institute over a period of year, a  patient control analgesia (PCA) total amount of morphine utilized to attain pain scores of 0-1 was measured in placebo, Ropivacaine and Levo-bupivacanie group  using visual analog score (VAS). Data was analyzed using analysis of variance and tests of statistical significance were employed.   

Results:  Significant difference was not observed between the Ropivacaine and Levo-bupivacaine groups with similar utilization of morphine for both drugs. Whereas significant difference was noted between placebo and local anaesthetics. 

Conclusions: There appear to be no difference between Ropivacaine and Levo-bupivacaine in terms of pain relief. Pre-emptive instillation of local anaesthetic for laparoscopic surgery is beneficial for post-operative pain relief.

Background & Objectives: The COVID-19 pandemic has created
significant effect on well-being, health, economic and social system
of the country. However, dearth of studies has explored the effect of
COVID-19 individual as well as social system. Therefore, the study
aimed to assess the effect of COVID-19 on psychological and physical
health of individual and educational system. Methods: An online
questionnaire that assesses the individual perspective about effect of
COVID-19 on health and educational system was framed and was
filled by 400 participants. From this, 20 questionnaires were invalid
or not completed. Therefore the data of 380 participants were presented
using descriptive statistics. Results: Most respondents were male, 15
to 30 years of age, post graduated, single, and working in agriculture
sector. Most of the respondents have monthly income of less than
20,000 and expenditure of 5000 and above. Participants have agreed
with the statement that monthly income, education has affected and
savings, addiction or smoking got decreased during lockdown. Food
habits have been changed. Health problems, practicing vipasyana, level
of stress, and internet surfing has increased during lockdown. People
were spending their most of the time with family during lockdown.
Daily wage workers were most affected group in this pandemic induced
lockdown situation. Conclusion: COVID-19 has impacted education
system. This lockdown situation has affected physical and psychological
health, economic condition of individuals. These impacts should
be considered in policy making related to these areas in this pandemic
situation.

Keywords: Covid-19, Lockdown; descriptive statistics, India, Education, Health, Psychological, Stress.

Background & Objectives: The COVID-19 pandemic has created
significant effect on well-being, health, economic and social system
of the country. However, dearth of studies has explored the effect of
COVID-19 individual as well as social system. Therefore, the study
aimed to assess the effect of COVID-19 on psychological and physical
health of individual and educational system. Methods: An online
questionnaire that assesses the individual perspective about effect of
COVID-19 on health and educational system was framed and was
filled by 400 participants. From this, 20 questionnaires were invalid
or not completed. Therefore the data of 380 participants were presented
using descriptive statistics. Results: Most respondents were male, 15
to 30 years of age, post graduated, single, and working in agriculture
sector. Most of the respondents have monthly income of less than
20,000 and expenditure of 5000 and above. Participants have agreed
with the statement that monthly income, education has affected and
savings, addiction or smoking got decreased during lockdown. Food
habits have been changed. Health problems, practicing vipasyana, level
of stress, and internet surfing has increased during lockdown. People
were spending their most of the time with family during lockdown.
Daily wage workers were most affected group in this pandemic induced
lockdown situation. Conclusion: COVID-19 has impacted education
system. This lockdown situation has affected physical and psychological
health, economic condition of individuals. These impacts should
be considered in policy making related to these areas in this pandemic
situation.

Keywords: Covid-19, Lockdown; descriptive statistics, India, Education, Health, Psychological, Stress.

Epistaxis means bleeding from the nose. It is a common clinical condition-encountered by the otorhinolaryngologist. In antique medicine, bleeding from the nose has been concepted with great curiosity. Severe epistaxis still constitutes a clinical problem and a challenge in otorhinolaryngology practice. The causes of epistaxis are numerous which can be divided into local and general causes. Common local causes are Trauma, Infections, Foreign bodies, Deviated nasal septum, Neoplasms. General causes are Hypertension, Blood dyscrasias, Chronic liver disorders, Chronic kidney diseases, Overuse of salicylates and anticoagulants. The present work has been undertaken to study the etiopathogenesis and management of epistaxis by different methods such as medical line of management, chemical cautery, anterior and posterior nasal packing, arterial ligation and surgical methods. Objective of the given is to evaluate the cause of epistaxis in 50 cases of age 1-15 years selected at random, with the help of relevant investigation and to find out the modality of treatment for the control of epistaxis. This study shows how important is to remove the primary cause in controlling epistaxis.

KEYWORDS: Epistaxis, Modality of treatment, Aetiopathology of epistaxis.

Epistaxis means bleeding from the nose. It is a common clinical condition-encountered by the otorhinolaryngologist. In antique medicine, bleeding from the nose has been concepted with great curiosity. Severe epistaxis still constitutes a clinical problem and a challenge in otorhinolaryngology practice. The causes of epistaxis are numerous which can be divided into local and general causes. Common local causes are Trauma, Infections, Foreign bodies, Deviated nasal septum, Neoplasms. General causes are Hypertension, Blood dyscrasias, Chronic liver disorders, Chronic kidney diseases, Overuse of salicylates and anticoagulants. The present work has been undertaken to study the etiopathogenesis and management of epistaxis by different methods such as medical line of management, chemical cautery, anterior and posterior nasal packing, arterial ligation and surgical methods. Objective of the given is to evaluate the cause of epistaxis in 50 cases of age 1-15 years selected at random, with the help of relevant investigation and to find out the modality of treatment for the control of epistaxis. This study shows how important is to remove the primary cause in controlling epistaxis.

KEYWORDS: Epistaxis, Modality of treatment, Aetiopathology of epistaxis.

Epistaxis means bleeding from the nose. It is a common clinical condition-encountered by the otorhinolaryngologist. In antique medicine, bleeding from the nose has been concepted with great curiosity. Severe epistaxis still constitutes a clinical problem and a challenge in otorhinolaryngology practice. The causes of epistaxis are numerous which can be divided into local and general causes. Common local causes are Trauma, Infections, Foreign bodies, Deviated nasal septum, Neoplasms. General causes are Hypertension, Blood dyscrasias, Chronic liver disorders, Chronic kidney diseases, Overuse of salicylates and anticoagulants. The present work has been undertaken to study the etiopathogenesis and management of epistaxis by different methods such as medical line of management, chemical cautery, anterior and posterior nasal packing, arterial ligation and surgical methods. Objective of the given is to evaluate the cause of epistaxis in 50 cases of age 1-15 years selected at random, with the help of relevant investigation and to find out the modality of treatment for the control of epistaxis. This study shows how important is to remove the primary cause in controlling epistaxis.

KEYWORDS: Epistaxis, Modality of treatment, Aetiopathology of epistaxis.

TP53 is a gene and the p53 is its protein product. It is well known as a tumor suppressor gene, due to its inherent property of apoptosis and its role in the suppression of tumor formation. Its oncogenic property is due to p53 mutation. This oncogenic property is named “gain of oncogenic property”. The functions of p53 have been studied the world over, especially the oncogenic function. It is well known for its role to induce apoptosis, but now it is established that it is also a key player in cell cycle regulation. It controls and monitors the cell division, chromosomal segregation, and cellular senescence. Due to all these important cellular functions, this protein is labeled as the “guardian of the genome”. The p53 protein is a nuclear phosphoprotein. It is composed of 393 amino acids. The structural and functional domains are an N-terminal transactivation domain, a protein-rich regulatory domain, and a C-terminal domain involved in the regulation of DNA binding. The colorectal cancers (CRC) are a major cause of morbidity and mortality world over. This is the third most common cancer worldwide and the fourth most common cause of death. Although it is slow-growing cancer the five-year survival is low. It is a heterogeneous disease and is due to, a complex genetic and biochemical interplay. This review summarizes the functions of p53 and its role in CRC.  

Keywords: TP53, p53, colorectal cancers, CRC, Tumor suppressor gene, apoptosis, cellular senescence, guardian of the genome.

TP53 is a gene and the p53 is its protein product. It is well known as a tumor suppressor gene, due to its inherent property of apoptosis and its role in the suppression of tumor formation. Its oncogenic property is due to p53 mutation. This oncogenic property is named “gain of oncogenic property”. The functions of p53 have been studied the world over, especially the oncogenic function. It is well known for its role to induce apoptosis, but now it is established that it is also a key player in cell cycle regulation. It controls and monitors the cell division, chromosomal segregation, and cellular senescence. Due to all these important cellular functions, this protein is labeled as the “guardian of the genome”. The p53 protein is a nuclear phosphoprotein. It is composed of 393 amino acids. The structural and functional domains are an N-terminal transactivation domain, a protein-rich regulatory domain, and a C-terminal domain involved in the regulation of DNA binding. The colorectal cancers (CRC) are a major cause of morbidity and mortality world over. This is the third most common cancer worldwide and the fourth most common cause of death. Although it is slow-growing cancer the five-year survival is low. It is a heterogeneous disease and is due to, a complex genetic and biochemical interplay. This review summarizes the functions of p53 and its role in CRC.  

Keywords: TP53, p53, colorectal cancers, CRC, Tumor suppressor gene, apoptosis, cellular senescence, guardian of the genome.

TP53 is a gene and the p53 is its protein product. It is well known as a tumor suppressor gene, due to its inherent property of apoptosis and its role in the suppression of tumor formation. Its oncogenic property is due to p53 mutation. This oncogenic property is named “gain of oncogenic property”. The functions of p53 have been studied the world over, especially the oncogenic function. It is well known for its role to induce apoptosis, but now it is established that it is also a key player in cell cycle regulation. It controls and monitors the cell division, chromosomal segregation, and cellular senescence. Due to all these important cellular functions, this protein is labeled as the “guardian of the genome”. The p53 protein is a nuclear phosphoprotein. It is composed of 393 amino acids. The structural and functional domains are an N-terminal transactivation domain, a protein-rich regulatory domain, and a C-terminal domain involved in the regulation of DNA binding. The colorectal cancers (CRC) are a major cause of morbidity and mortality world over. This is the third most common cancer worldwide and the fourth most common cause of death. Although it is slow-growing cancer the five-year survival is low. It is a heterogeneous disease and is due to, a complex genetic and biochemical interplay. This review summarizes the functions of p53 and its role in CRC.  

Keywords: TP53, p53, colorectal cancers, CRC, Tumor suppressor gene, apoptosis, cellular senescence, guardian of the genome.

Abstract - Hiatus hernia (HH) is the herniation of stomach into the chest cavity through diaphragm. HH is idiopathic and hence its exact cause is not known; possible causes are age related changes in diaphragm and inborn large hiatus. [1] Cameron lesions are yet another indicative for hiatus hernia. The purpose of this case report is highlighting various sources of the above condition which lead to worsened patient condition leading to hospitalization.

Current case is a presentation of heme fibroid, duodenal Cameron lesion and type 1 hiatus hernia leading to worsened iron deficiency anaemia. For the efficient management of patient a proton pump inhibitor and vitamin B complex was advised.

Key words:  Hiatus Hernia, Iron deficiency Anemia, Proton Pump Inhibitor, Heme Fibroid

Abstract - Hiatus hernia (HH) is the herniation of stomach into the chest cavity through diaphragm. HH is idiopathic and hence its exact cause is not known; possible causes are age related changes in diaphragm and inborn large hiatus. [1] Cameron lesions are yet another indicative for hiatus hernia. The purpose of this case report is highlighting various sources of the above condition which lead to worsened patient condition leading to hospitalization.

Current case is a presentation of heme fibroid, duodenal Cameron lesion and type 1 hiatus hernia leading to worsened iron deficiency anaemia. For the efficient management of patient a proton pump inhibitor and vitamin B complex was advised.

Key words:  Hiatus Hernia, Iron deficiency Anemia, Proton Pump Inhibitor, Heme Fibroid

Abstract - Hiatus hernia (HH) is the herniation of stomach into the chest cavity through diaphragm. HH is idiopathic and hence its exact cause is not known; possible causes are age related changes in diaphragm and inborn large hiatus. [1] Cameron lesions are yet another indicative for hiatus hernia. The purpose of this case report is highlighting various sources of the above condition which lead to worsened patient condition leading to hospitalization.

Current case is a presentation of heme fibroid, duodenal Cameron lesion and type 1 hiatus hernia leading to worsened iron deficiency anaemia. For the efficient management of patient a proton pump inhibitor and vitamin B complex was advised.

Key words:  Hiatus Hernia, Iron deficiency Anemia, Proton Pump Inhibitor, Heme Fibroid