Electrophysiology of LHON eyes may strongly depend on genetics, drugs, and multisystem involvement

Josef Finsterer, MD, PhD*

Electrophysiology of LHON eyes may strongly depend on genetics, drugs, and multisystem involvement

Josef Finsterer, MD, PhD*

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Josef Finsterer, MD, PhD*, “Electrophysiology of LHON eyes may strongly depend on genetics, drugs, and multisystem involvement”, ijmhs, vol. 10, no. 06, pp. 916–917, Jun. 2020.

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Abstract

With interest we read the article by Wang et al. about
a retrospective study of 13 Chinese patients with Leber’s
hereditary optic neuropathy (LHON) by means of optical
coherence tomography (OCT), visually-evoked potentials
(VEPs), and pattern- / multifocal electroretinography
(p/mfERGfERG) [1]. The authors found disc hyperemia
vs. optic atrophy, normal vs. reduced retinal nerve fibre
layer (RNFL) thickness, and mild, subnormal mfERG responses
vs. reduced mfERG responses in the early respectively
chronic stages of the disease. We have the following
comments and concerns.
A major shortcoming of the study is that it had a retrospective
design and that thus reproducibility of the results
or inter-observer variabilities were not tested.

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[1]

Josef Finsterer, MD, PhD*, “Electrophysiology of LHON eyes may strongly depend on genetics, drugs, and multisystem involvement”, ijmhs, vol. 10, no. 06, pp. 916–917, Jun. 2020.

Issue Vol. 10 No. 06 (2020): Innovative Journal of Medical and Health Science
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Electrophysiology of LHON eyes may strongly depend on genetics, drugs, and multisystem involvement

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