Assessing the effect of idebenone in LHON by silent-MT 7T-MRI of the optic nerve requires appropriate study designs

Josef Finsterer, MD, PhD*

Assessing the effect of idebenone in LHON by silent-MT 7T-MRI of the optic nerve requires appropriate study designs

Josef Finsterer, MD, PhD*

Cite this:

[1]

Josef Finsterer, MD, PhD*, “Assessing the effect of idebenone in LHON by silent-MT 7T-MRI of the optic nerve requires appropriate study designs”, ijmhs, vol. 10, no. 06, pp. 918–919, Jun. 2020.

RIGHTS & PERMISSIONS

Article Views

279

Altmetric

Citations

LEARN ABOUT THESE METRICS

Abstract

With interest we read the article by Grochowski et al.
about an investigation of the optic nerves in 6 patients
with Leber’s hereditary optic neuropathy (LHON) receiving
idebenone and 9 LHON patients not receiving idebenone by
means of a Zero Echo Time (ZET) 7T MRI sequence with
an Adiabatic Spectral Inversion Recovery (ASPIR) fat suppression
pulse (silent-MT 7T-MRI) [1]. It was concluded
that the technique confirms known pathology of the optic
nerve in LHON [1]. We have the following comments and
concerns.
We disagree with the notion that ‘LHON is a disorder of
the optic nerve. LHON is pirmarely a disorder of the retinal
ganglion cells (RGCs), which is why it can be diagnosed by
the ophthalmologist. Secondarily, LHON affects dendrites
and axons of RGCs resulting in asymmetric optic atrophy.
There are no striking conclusions from this study. The
only results were that the silent-MT at 7T depicts the optic
nerve with high quality and artefact-free, that quantitative
measures of the optic nerve can be obtained, and that
LHON optic nerves showed focal hyperintensities.
The authors do not differentiate b etween L HON and
LHON plus [2]. LHON exclusively affects t he retina,
whereas LHON plus is characterised by multiorgan involvement,
affecting i n p articular t he e yes b ut a lso t he brain,
endocrine organs, bone marrow, arteries, kidneys, peripheral
nerves, and the heart [2]. We should know how many
of the included patients had LHON and how many LHON
plus. This is crucial as it may determine the outcome of
these patients [3].

Content

Part of special issue:

Innovative Journal of Medical and Health Science

Article Metrics by Journal Systems

Citations not available
Readers 279
Download 131

Altmetric Attention score:

Altmetric badge

Share this article

Source

How to Cite

[1]

Issue Vol. 10 No. 06 (2020): Innovative Journal of Medical and Health Science
Section Research Articles

License

All paper submissions must carry the following duly signed by all the authors:
â€œI certify that I have participated sufficiently in the conception and design of this work and the analysis of the data (wherever applicable), as well as the writing of the manuscript, to take public responsibility for it. I believe the manuscript represents valid work. I have reviewed the final version of the manuscript and approve it for publication. Neither has the manuscript nor one with substantially similar content under my authorship been published nor is being considered for publication elsewhere, except as described in an attachment. Furthermore I attest that I shall produce the data upon which the manuscript is based for examination by the editors or their assignees, if requested.â€

Innovative Journal of Medical and Health Sciences

Assessing the effect of idebenone in LHON by silent-MT 7T-MRI of the optic nerve requires appropriate study designs

Article Views

Altmetric

Citations

Abstract

Special Issue

Article Metrics Graph

Content

Section

Source

License

Most read articles by the same author(s)