Innovative Journal of Medical and Health Sciences

Introduction: Prevention of dental caries and non-carious lesions associated with
demineralizing effect of estrogen imbalance in perimenopause women is
relevant problem in modern dentistry.
The aim: To improve the effectiveness of prevention of caries and non-carious
lesions in female patients with estrogen imbalance.
Materials and methods: 3 groups of patients were selected for the study (20
women in each): the patients of the control group receiving no additional
treatment, the patients of experimental group 1 receiving general therapy with
complex calcium supplements, the patients of experimental group 2 receiving
general therapy of complex calcium medicines combined with
aminobisphosphonates.
To quantify bone density of the jaws by computed tomography method, X-ray
attenuation scale, called the Hounsfield scale was used. Bone tissues of the jaws
were studied using 3D cone beam computed tomography scanner Planmeca
ProMax. Planmeca Romexis® software was used for data processing and
interpretation. Estrogen level was estimated in all patients to confirm its
imbalance. The level of serum acid phosphatase was determined for indirect
study of osteoporosis degree.
Results: At the beginning of the research, significant bone demineralization and
increased level of acidic phosphatase were observed in all groups of women. In
6 months of treatment the Hounsfield index and the level of acidic phosphatase
in the control group were almost unchanged; in experimental group 1 – 1571
±44 HU and 4.93 ± 0.26 IU/l; in experimental group 2 – 1701±48 HU and 2.43
± 0.18 IU/l.
Conclusions: Combination therapy consisting of calcium phosphate with
vitamin D3 and aminobisphosphonates used for 6 months increased bone
mineralization by 13.05% and reduced the activity of acid phosphatase by
64.2%. This therapeutic complex results in decreased destruction of bone tissue
and enhances remineralization of bone tissue and dental hard tissues.
Key words: teeth mineralization, osteoporosis, estrogen dysfunction, Hounsfield
index.

Kleine-levin syndrome is characterized as a periodic hypersomnia crisis as well as changes in appetite and variable behavioural symptoms. The exact aetiology is unknown and it is diagnosed based on clinical manifestations.  This report describes the finding of a 15- year- old boy with KLS. He presented with hypersomnia, auditory hallucinations and persecutory delusions and all the episodes started with skin lesions over the leg. He had amnesia to his episodes. Kleine-levin syndrome should be considered in patients with periodic hypersomnia and skin lesions. The objective of this case report is that clinicians should have a high index of suspicion of Kleine Levin syndrome in case of periodic hypersomnia.

Coronaviruses (Cov) are a large family of viruses that cause illness ranging from the common cold to move severe diseases such as Middle East Respiratory Syndrome (MERS-CoV). A novel coronavirus (nCOV) is a new strain that that not been previously identified in humans.
Coronaviruses are zoonatic, meaning they are transmitted between animals and people. According to many investigations it has been found that SARS-CoV from dromedary camels to humans. Several known coronaviruses are circulating in animals that have not yet infected humans.