Innovative Journal of Medical and Health Sciences

This experimental animal study aimed to assess the potentially positive effect of
the administration of beta-blocker propranolol on the osseointegration procedure of
stainless-steel bone implants. It was performed in two groups (study, control), consisting
of 15 adult (12-weeks old) male Wistar albino rats each. In the proximal metaphysis
of each tibia of all animals, a custom designed stainless-steel screw was implanted
under sedation on day 0. Starting on the first postoperative day, study group animals
received 2.5mg/kgr (1mg/ml) of propranolol daily intraperitoneally. Control
group received the same volume of saline. On day 29, all animals were euthanized,
both tibias from each animal were harvested and the implants’ pullout-strength and
removal torque were assessed. All animals completed the study and all harvested
tibias were suitable for evaluation. Both parameters were different between the two
groups, favoring the study group, albeit in a non-statistically significant manner. The
pullout-strength and its Standard Deviation was 104.221.3 Newtons (study group)
versus 90.818.2 Newtons (p=0.103), removal torque was 5.40.8 Newtons/cm (study
group) versus 4.90.7 Newtons/cm (p=0.09). No statistically significant correlation
was found between the animal weight and the pullout strength (p=0.159, rs=-0.279),
the animal weight and the removal torque (p=0.628, rs=-0.101) and between the pullout
strength and the removal torque (p=0.193, r=0.258). Propranolol administration
seems to act positively on the osseointegration procedure of stainless-steel bone implants,
albeit in a non-statistically significant manner. Further studies will be needed
to reach secure conclusions regarding the potential beneficial effect of beta-blocker
propranolol on bone implants’ osseointegration.
Key words: Propranolol–osseointegration–prosthetic implants–prosthesis–beta
adrenergic blocker agents

This experimental animal study aimed to assess the potentially positive effect of
the administration of beta-blocker propranolol on the osseointegration procedure of
stainless-steel bone implants. It was performed in two groups (study, control), consisting
of 15 adult (12-weeks old) male Wistar albino rats each. In the proximal metaphysis
of each tibia of all animals, a custom designed stainless-steel screw was implanted
under sedation on day 0. Starting on the first postoperative day, study group animals
received 2.5mg/kgr (1mg/ml) of propranolol daily intraperitoneally. Control
group received the same volume of saline. On day 29, all animals were euthanized,
both tibias from each animal were harvested and the implants’ pullout-strength and
removal torque were assessed. All animals completed the study and all harvested
tibias were suitable for evaluation. Both parameters were different between the two
groups, favoring the study group, albeit in a non-statistically significant manner. The
pullout-strength and its Standard Deviation was 104.221.3 Newtons (study group)
versus 90.818.2 Newtons (p=0.103), removal torque was 5.40.8 Newtons/cm (study
group) versus 4.90.7 Newtons/cm (p=0.09). No statistically significant correlation
was found between the animal weight and the pullout strength (p=0.159, rs=-0.279),
the animal weight and the removal torque (p=0.628, rs=-0.101) and between the pullout
strength and the removal torque (p=0.193, r=0.258). Propranolol administration
seems to act positively on the osseointegration procedure of stainless-steel bone implants,
albeit in a non-statistically significant manner. Further studies will be needed
to reach secure conclusions regarding the potential beneficial effect of beta-blocker
propranolol on bone implants’ osseointegration.
Key words: Propranolol–osseointegration–prosthetic implants–prosthesis–beta
adrenergic blocker agents

This experimental animal study aimed to assess the potentially positive effect of
the administration of beta-blocker propranolol on the osseointegration procedure of
stainless-steel bone implants. It was performed in two groups (study, control), consisting
of 15 adult (12-weeks old) male Wistar albino rats each. In the proximal metaphysis
of each tibia of all animals, a custom designed stainless-steel screw was implanted
under sedation on day 0. Starting on the first postoperative day, study group animals
received 2.5mg/kgr (1mg/ml) of propranolol daily intraperitoneally. Control
group received the same volume of saline. On day 29, all animals were euthanized,
both tibias from each animal were harvested and the implants’ pullout-strength and
removal torque were assessed. All animals completed the study and all harvested
tibias were suitable for evaluation. Both parameters were different between the two
groups, favoring the study group, albeit in a non-statistically significant manner. The
pullout-strength and its Standard Deviation was 104.221.3 Newtons (study group)
versus 90.818.2 Newtons (p=0.103), removal torque was 5.40.8 Newtons/cm (study
group) versus 4.90.7 Newtons/cm (p=0.09). No statistically significant correlation
was found between the animal weight and the pullout strength (p=0.159, rs=-0.279),
the animal weight and the removal torque (p=0.628, rs=-0.101) and between the pullout
strength and the removal torque (p=0.193, r=0.258). Propranolol administration
seems to act positively on the osseointegration procedure of stainless-steel bone implants,
albeit in a non-statistically significant manner. Further studies will be needed
to reach secure conclusions regarding the potential beneficial effect of beta-blocker
propranolol on bone implants’ osseointegration.
Key words: Propranolol–osseointegration–prosthetic implants–prosthesis–beta
adrenergic blocker agents

This experimental animal study aimed to assess the potentially positive effect of
the administration of beta-blocker propranolol on the osseointegration procedure of
stainless-steel bone implants. It was performed in two groups (study, control), consisting
of 15 adult (12-weeks old) male Wistar albino rats each. In the proximal metaphysis
of each tibia of all animals, a custom designed stainless-steel screw was implanted
under sedation on day 0. Starting on the first postoperative day, study group animals
received 2.5mg/kgr (1mg/ml) of propranolol daily intraperitoneally. Control
group received the same volume of saline. On day 29, all animals were euthanized,
both tibias from each animal were harvested and the implants’ pullout-strength and
removal torque were assessed. All animals completed the study and all harvested
tibias were suitable for evaluation. Both parameters were different between the two
groups, favoring the study group, albeit in a non-statistically significant manner. The
pullout-strength and its Standard Deviation was 104.221.3 Newtons (study group)
versus 90.818.2 Newtons (p=0.103), removal torque was 5.40.8 Newtons/cm (study
group) versus 4.90.7 Newtons/cm (p=0.09). No statistically significant correlation
was found between the animal weight and the pullout strength (p=0.159, rs=-0.279),
the animal weight and the removal torque (p=0.628, rs=-0.101) and between the pullout
strength and the removal torque (p=0.193, r=0.258). Propranolol administration
seems to act positively on the osseointegration procedure of stainless-steel bone implants,
albeit in a non-statistically significant manner. Further studies will be needed
to reach secure conclusions regarding the potential beneficial effect of beta-blocker
propranolol on bone implants’ osseointegration.
Key words: Propranolol–osseointegration–prosthetic implants–prosthesis–beta
adrenergic blocker agents

This experimental animal study aimed to assess the potentially positive effect of
the administration of beta-blocker propranolol on the osseointegration procedure of
stainless-steel bone implants. It was performed in two groups (study, control), consisting
of 15 adult (12-weeks old) male Wistar albino rats each. In the proximal metaphysis
of each tibia of all animals, a custom designed stainless-steel screw was implanted
under sedation on day 0. Starting on the first postoperative day, study group animals
received 2.5mg/kgr (1mg/ml) of propranolol daily intraperitoneally. Control
group received the same volume of saline. On day 29, all animals were euthanized,
both tibias from each animal were harvested and the implants’ pullout-strength and
removal torque were assessed. All animals completed the study and all harvested
tibias were suitable for evaluation. Both parameters were different between the two
groups, favoring the study group, albeit in a non-statistically significant manner. The
pullout-strength and its Standard Deviation was 104.221.3 Newtons (study group)
versus 90.818.2 Newtons (p=0.103), removal torque was 5.40.8 Newtons/cm (study
group) versus 4.90.7 Newtons/cm (p=0.09). No statistically significant correlation
was found between the animal weight and the pullout strength (p=0.159, rs=-0.279),
the animal weight and the removal torque (p=0.628, rs=-0.101) and between the pullout
strength and the removal torque (p=0.193, r=0.258). Propranolol administration
seems to act positively on the osseointegration procedure of stainless-steel bone implants,
albeit in a non-statistically significant manner. Further studies will be needed
to reach secure conclusions regarding the potential beneficial effect of beta-blocker
propranolol on bone implants’ osseointegration.
Key words: Propranolol–osseointegration–prosthetic implants–prosthesis–beta
adrenergic blocker agents

Introduction: Quality of life(QOL) is a complicated and multidimensional
measure that affects the diagnosis and impact the treatment of a disease. QOL
continuously impacts the daily lives and activities of patients with breast cancer
during and after recovery. The current study aimed to: identify the
relationship between bio socio-demographic characteristics and quality of life
of women identify the relationship between bio socio-demographic
characteristics and quality of life of women undergone surgery as a treatment
for breast cancer. Methodology: a descriptive cross-sectional design was
adopted. Data was collected by conducting home visits for 120 randomly
elected adult women who had undergone breast surgery as a treatment for
breast cancer. Bio-socio-demographic structured interview schedule, QLQ-C30
and QLQ-C23 were used for data collection. Results: there was significantly
higher frequencies effect of marital status, tumor condition before surgery,
client’s activity and time period between diagnosis & surgery as predictors on
QLQ-C30 (p = <0.01). While; education, family income, family housing and
after surgery treatment had slight significance frequencies effect on QLQ-C30
(p < 0.05). significantly higher frequencies effect of family housing, tumor
condition before surgery, activity level and time period between diagnosis &
surgery as predictors on QLQ-C23 (p = <0.01). While; education, marital status
and after surgery treatment has slight significance frequencies effect on QLQ-
C23 (p < 0.05). But, occupation, breast cancer stage, after surgery medical
problem and family history were not predicted by relation to QLQ-C23 (p >
0.05). Conclusion: The overall quality of life of the study participants was
below average compared to international references. Functional and symptom
scales were affected in women after surgery. There was significantly higher
frequencies effect of demographic factors as marital status, education, family
income, family housing and clinical characteristics as tumor condition before
surgery, breast cancer stage, client’s activity, time period between diagnosis &
surgery and post-surgery treatment as predictors on QLQ-C30 and QLQ-C23.
While, age, occupation, after surgery medical problem and family history were
not predicted by relation to participants’ quality of life. Key words: Breast
cancer, quality of life, therapy impact, breast cancer survivals

India has been a cradle of martial arts that has been diffused to other parts of the
globe as well. Siddha system is one among the traditional system of Indian medicine
originated in Tamilnadu of South India. According to this system, the human body
constitution is made up of three basic subtle components named as Vatham, Pitham,
Kapham. These three components are altogether known as three humours(Uyir
thaathukkal). The Siddha theory states that diseases are caused by the derangements
one or more of these three humours. In that way the derangement of Vatham humour
is responsible for pain related disorders. Though Siddha system has numerous internal
medicines and external therapies to manage pain, Varmam is considered to be an
unique martial art of pain management by stimulating Varma points(Vital points).
These Varma points are interlinked with one another in the human body and the
energy circulation between the Varma points are called as ‘saram(circulation of energy)’.
Such aspects of traditional martial practices are not normally recognised by
present day western scientific community, which tend to criticize them labelling as
‘arts’ or ‘sports’. However, through this paper the very combination of medically relevant
aspects of varmam for the management of pain has been scientifically explored.
The study results revealed that upon carefully analyzing the Siddha literature, these
varma points seem to correlate well with the physiological analgesic pathway of Brain
opiate system claiming varmam as not only a complementary, but as the most decisive
feature of Siddha system of medicine.
Key words: External therapy–Varma therapy–Indian medicine–Martial art–
traditional medicine

India has been a cradle of martial arts that has been diffused to other parts of the
globe as well. Siddha system is one among the traditional system of Indian medicine
originated in Tamilnadu of South India. According to this system, the human body
constitution is made up of three basic subtle components named as Vatham, Pitham,
Kapham. These three components are altogether known as three humours(Uyir
thaathukkal). The Siddha theory states that diseases are caused by the derangements
one or more of these three humours. In that way the derangement of Vatham humour
is responsible for pain related disorders. Though Siddha system has numerous internal
medicines and external therapies to manage pain, Varmam is considered to be an
unique martial art of pain management by stimulating Varma points(Vital points).
These Varma points are interlinked with one another in the human body and the
energy circulation between the Varma points are called as ‘saram(circulation of energy)’.
Such aspects of traditional martial practices are not normally recognised by
present day western scientific community, which tend to criticize them labelling as
‘arts’ or ‘sports’. However, through this paper the very combination of medically relevant
aspects of varmam for the management of pain has been scientifically explored.
The study results revealed that upon carefully analyzing the Siddha literature, these
varma points seem to correlate well with the physiological analgesic pathway of Brain
opiate system claiming varmam as not only a complementary, but as the most decisive
feature of Siddha system of medicine.
Key words: External therapy–Varma therapy–Indian medicine–Martial art–
traditional medicine

India has been a cradle of martial arts that has been diffused to other parts of the
globe as well. Siddha system is one among the traditional system of Indian medicine
originated in Tamilnadu of South India. According to this system, the human body
constitution is made up of three basic subtle components named as Vatham, Pitham,
Kapham. These three components are altogether known as three humours(Uyir
thaathukkal). The Siddha theory states that diseases are caused by the derangements
one or more of these three humours. In that way the derangement of Vatham humour
is responsible for pain related disorders. Though Siddha system has numerous internal
medicines and external therapies to manage pain, Varmam is considered to be an
unique martial art of pain management by stimulating Varma points(Vital points).
These Varma points are interlinked with one another in the human body and the
energy circulation between the Varma points are called as ‘saram(circulation of energy)’.
Such aspects of traditional martial practices are not normally recognised by
present day western scientific community, which tend to criticize them labelling as
‘arts’ or ‘sports’. However, through this paper the very combination of medically relevant
aspects of varmam for the management of pain has been scientifically explored.
The study results revealed that upon carefully analyzing the Siddha literature, these
varma points seem to correlate well with the physiological analgesic pathway of Brain
opiate system claiming varmam as not only a complementary, but as the most decisive
feature of Siddha system of medicine.
Key words: External therapy–Varma therapy–Indian medicine–Martial art–
traditional medicine

Promote a critical and updated reflection on the articulation between the Family
Health Strategy and the Psychosocial Care Center, demonstrating its importance and
the problems faced by analyzing articles on the articulation between these two specialized
services, providing a better understanding of the subject and emphasizing the
need for research in this area of activity. We opted for a qualitative approach, because
of a literature review of contemporary scientific articles relevant to the theme, taken
from the bases of Lilacs and Scielo to compose the theoretical framework. There are
several obstacles to the articulation work between the two service networks. It makes
necessary to build a structured and adequate knowledge to meet the complexity of
the demands of those who seek help from both devices for comprehensive health monitoring
mental, being necessary to resort to the matrix. It was concluded that in the
organization of the mental health network, the relationship between CAPS activities
and the FHS appears more as theoretical principles and not as they should occur in
daily life, demonstrating that there is still a gap between the guidelines proposed by
the health policy, mental and concrete practices.
Key words: Mental Health–Health Strategy–Psychosocial Care.

Serum Procalcitonin (PCT) is a biomarker and it widely studied to guide antibiotic
treatment in septic patients. This study considered the diagnostic accuracy of PCT in
sepsis or septic shock patient and how diagnosis of serum PCT will impact on antibiotic
intervention. PCT level was examined at baseline and regular interval to manage dose
of antibiotics. After PCT implementation 82.48% patients were discharged and it also
decreased hospital stay.
We conclude that there was a significant decreased extra use of broad spectrum antibiotics;
length of stay in hospital, cost of hospitalization after the implementation of
PCT. PCT values had a higher predictive usefulness for proper management of sepsis
and decrease use of antibiotics.
Key words: PCT–Sepsis–Antibiotic therapy etc

Serum Procalcitonin (PCT) is a biomarker and it widely studied to guide antibiotic
treatment in septic patients. This study considered the diagnostic accuracy of PCT in
sepsis or septic shock patient and how diagnosis of serum PCT will impact on antibiotic
intervention. PCT level was examined at baseline and regular interval to manage dose
of antibiotics. After PCT implementation 82.48% patients were discharged and it also
decreased hospital stay.
We conclude that there was a significant decreased extra use of broad spectrum antibiotics;
length of stay in hospital, cost of hospitalization after the implementation of
PCT. PCT values had a higher predictive usefulness for proper management of sepsis
and decrease use of antibiotics.
Key words: PCT–Sepsis–Antibiotic therapy etc

Serum Procalcitonin (PCT) is a biomarker and it widely studied to guide antibiotic
treatment in septic patients. This study considered the diagnostic accuracy of PCT in
sepsis or septic shock patient and how diagnosis of serum PCT will impact on antibiotic
intervention. PCT level was examined at baseline and regular interval to manage dose
of antibiotics. After PCT implementation 82.48% patients were discharged and it also
decreased hospital stay.
We conclude that there was a significant decreased extra use of broad spectrum antibiotics;
length of stay in hospital, cost of hospitalization after the implementation of
PCT. PCT values had a higher predictive usefulness for proper management of sepsis
and decrease use of antibiotics.
Key words: PCT–Sepsis–Antibiotic therapy etc

Aim: This study was designed to analyze the perception of spirituality and
spiritual support of students studying at faculties of health sciences.
Materials and Methodology: This descriptive study population was collected of
1382 students receiving education at the departments of Nutrition and Dietetics,
Pediatric Development, Physical Therapy and Rehabilitation and Nursing and
Health Management of a Foundation University. Sampling method was not
preferred in this research but students who agreed to take part in the study were
included within its scope. Data was collected between January 3-8, 2018 and the
research was completed with 857 students. In addition, relevant data was collected
by means of “Individual Information Form” and “Spirituality and Spiritual Care
Rating Scale”. SPPS 24.0 statistical package software was used in the assessment of
the data.
Findings: It was determined that 37.7% of the students participating in the
research study are in the Department of Nutrition and Dietetics, 23% are 20 years
old and 84.7% are female. It was further determined that 27.4% are juniors, 77.2%
did not receive any education on spirituality and the majority of those who did
found the education on spirituality sufficient. The total mean score of all students
was determined as 53,60 ± 9,58 as a result of the “Spirituality and Spiritual Rating
Care Scale” evaluations in the study. There was no statistically significant
difference (p>0.05) between the mean score of the students according to their
departments and age variable. On the other hand, there was a statistically
significant difference (p<0.05) between the mean scale scores of the freshmen and
senior students in their departments. In addition, there was a statistically
significant difference (p<0.05) between the mean scale scores of the students who
received education on spirituality and those who did not.
Conclusion: the study reveals that students have an above average understanding
of spirituality and spiritual care, but do not receive sufficient education on the
subject. Therefore, there is a need for a higher level of education in this area. It is
recommended that educational institutions provide classes on spiritual care so
that students fill the gap in their knowledge.
Key Words: Spirituality, Spiritual Care, Health, Health Sciences Students

Introduction : Anatomy of proximal femur and acetabulum are very important in total hip replacement surgery. The objective of this study is to compare AD and Depth morphology in humans in terms of age and gender. . Multiplanar evaluation by computed tomography (CT) scan is the key to assess acetabular depth, version, and inclination.

Methods: In this retrospective Radiology based study, AD and Depth measurements of 100 randomly selected CT scans from patients who had came for diagnosis in  the Nearby randomly selected Secondary and Tertiary care Hospitals and Radiological Diagnostic centres The patients with surgical intervention, those with an orthopedic problem and those who had undergone acetabular dysplasia and hip arthroplasty were excluded. AD and Depth were performed unilaterally, from the left side.

Results: Measurement results showed that AD was 61.38 ± 3.41 mm in males & 58.25 ± 2.72 mm in females. Average depth was 19.01 ± 2.84 mm in males,& 18.27 ± 1.74 mm in females. Statistically significant difference was found between males and females in terms of AD , while no differences were found in terms of Depth. Correlation analysis results did not show a statistically significant correlation between AD and Depth (p>0.05).

Conclusions : The results of our study will contribute to studies about hip arthroplasty applications. In addition, we believe that a data base will be formed about this subject related with our region.

Focal seizure is a very rare side effect of Levofloxacin. According to Infectious Disease
Society of America (IDSA) Levofloxacin is a first line treatment of Pneumonia, Urinary
tract infections and abdominal infections. Here in we report a case of 65-year-old male
presenting to Emergency Medicine Department with chief complain of fever with chills
associated with rigors. Patient was a known case of Parkinson’s disease (PD). After
admission he was treated with Levofloxacin and after the fifth dose of Levofloxacin
patient had an attack of Focal seizure on his right hand. Focal seizure can emerge as
a rare but dangerous side effect of Levofloxacin.
Key words: Fluroquinolones–Focal seizure–Levofloxacin–Parkinson’s disease

Focal seizure is a very rare side effect of Levofloxacin. According to Infectious Disease
Society of America (IDSA) Levofloxacin is a first line treatment of Pneumonia, Urinary
tract infections and abdominal infections. Here in we report a case of 65-year-old male
presenting to Emergency Medicine Department with chief complain of fever with chills
associated with rigors. Patient was a known case of Parkinson’s disease (PD). After
admission he was treated with Levofloxacin and after the fifth dose of Levofloxacin
patient had an attack of Focal seizure on his right hand. Focal seizure can emerge as
a rare but dangerous side effect of Levofloxacin.
Key words: Fluroquinolones–Focal seizure–Levofloxacin–Parkinson’s disease

Focal seizure is a very rare side effect of Levofloxacin. According to Infectious Disease
Society of America (IDSA) Levofloxacin is a first line treatment of Pneumonia, Urinary
tract infections and abdominal infections. Here in we report a case of 65-year-old male
presenting to Emergency Medicine Department with chief complain of fever with chills
associated with rigors. Patient was a known case of Parkinson’s disease (PD). After
admission he was treated with Levofloxacin and after the fifth dose of Levofloxacin
patient had an attack of Focal seizure on his right hand. Focal seizure can emerge as
a rare but dangerous side effect of Levofloxacin.
Key words: Fluroquinolones–Focal seizure–Levofloxacin–Parkinson’s disease

Focal seizure is a very rare side effect of Levofloxacin. According to Infectious Disease
Society of America (IDSA) Levofloxacin is a first line treatment of Pneumonia, Urinary
tract infections and abdominal infections. Here in we report a case of 65-year-old male
presenting to Emergency Medicine Department with chief complain of fever with chills
associated with rigors. Patient was a known case of Parkinson’s disease (PD). After
admission he was treated with Levofloxacin and after the fifth dose of Levofloxacin
patient had an attack of Focal seizure on his right hand. Focal seizure can emerge as
a rare but dangerous side effect of Levofloxacin.
Key words: Fluroquinolones–Focal seizure–Levofloxacin–Parkinson’s disease

Focal seizure is a very rare side effect of Levofloxacin. According to Infectious Disease
Society of America (IDSA) Levofloxacin is a first line treatment of Pneumonia, Urinary
tract infections and abdominal infections. Here in we report a case of 65-year-old male
presenting to Emergency Medicine Department with chief complain of fever with chills
associated with rigors. Patient was a known case of Parkinson’s disease (PD). After
admission he was treated with Levofloxacin and after the fifth dose of Levofloxacin
patient had an attack of Focal seizure on his right hand. Focal seizure can emerge as
a rare but dangerous side effect of Levofloxacin.
Key words: Fluroquinolones–Focal seizure–Levofloxacin–Parkinson’s disease

Tuberculosis (TB) has existed for millennia and remains a major global health problem.
It causes ill-health in millions of people each year and in 2015 was one of the top
10 causes of death worldwide, ranking above HIV/AIDS as one of the leading causes of
death from an infectious disease. Erythroderma, or generalized exfoliative dermatitis
is an uncommon but serious skin disorder which results in generalized scaling eruption
of the skin. It is usually drug induced, idiopathic, or secondary to underlying cutaneous
or systemic diseases. Theoretically, any drug may cause exfoliative dermatitis.
Isoniazid is established the first-line antitubercular drug and an essential component
of all antitubercular regimens. Erythroderma caused by isoniazid is an uncommon but
serious adverse drug reaction. We report here a case of a 54-year-old male patient who
presented with generalized redness and exfoliation of skin with itching after 6 weeks of
antitubercular treatment (ATT). ATT was stopped immediately, and antihistaminics
and steroids were started. The patient improved over a period of 2 weeks. On sequential
rechallenge, she developed similar lesions all over the body with isoniazid, hence
confirming the diagnosis of isoniazid-induced erythroderma.
Key words: Adverse drug reaction–Erythroderma–or generalized exfoliative
dermatitis–Isoniazid–Tuberculosis

Tuberculosis (TB) has existed for millennia and remains a major global health problem.
It causes ill-health in millions of people each year and in 2015 was one of the top
10 causes of death worldwide, ranking above HIV/AIDS as one of the leading causes of
death from an infectious disease. Erythroderma, or generalized exfoliative dermatitis
is an uncommon but serious skin disorder which results in generalized scaling eruption
of the skin. It is usually drug induced, idiopathic, or secondary to underlying cutaneous
or systemic diseases. Theoretically, any drug may cause exfoliative dermatitis.
Isoniazid is established the first-line antitubercular drug and an essential component
of all antitubercular regimens. Erythroderma caused by isoniazid is an uncommon but
serious adverse drug reaction. We report here a case of a 54-year-old male patient who
presented with generalized redness and exfoliation of skin with itching after 6 weeks of
antitubercular treatment (ATT). ATT was stopped immediately, and antihistaminics
and steroids were started. The patient improved over a period of 2 weeks. On sequential
rechallenge, she developed similar lesions all over the body with isoniazid, hence
confirming the diagnosis of isoniazid-induced erythroderma.
Key words: Adverse drug reaction–Erythroderma–or generalized exfoliative
dermatitis–Isoniazid–Tuberculosis

Tuberculosis (TB) has existed for millennia and remains a major global health problem.
It causes ill-health in millions of people each year and in 2015 was one of the top
10 causes of death worldwide, ranking above HIV/AIDS as one of the leading causes of
death from an infectious disease. Erythroderma, or generalized exfoliative dermatitis
is an uncommon but serious skin disorder which results in generalized scaling eruption
of the skin. It is usually drug induced, idiopathic, or secondary to underlying cutaneous
or systemic diseases. Theoretically, any drug may cause exfoliative dermatitis.
Isoniazid is established the first-line antitubercular drug and an essential component
of all antitubercular regimens. Erythroderma caused by isoniazid is an uncommon but
serious adverse drug reaction. We report here a case of a 54-year-old male patient who
presented with generalized redness and exfoliation of skin with itching after 6 weeks of
antitubercular treatment (ATT). ATT was stopped immediately, and antihistaminics
and steroids were started. The patient improved over a period of 2 weeks. On sequential
rechallenge, she developed similar lesions all over the body with isoniazid, hence
confirming the diagnosis of isoniazid-induced erythroderma.
Key words: Adverse drug reaction–Erythroderma–or generalized exfoliative
dermatitis–Isoniazid–Tuberculosis

Tuberculosis (TB) has existed for millennia and remains a major global health problem.
It causes ill-health in millions of people each year and in 2015 was one of the top
10 causes of death worldwide, ranking above HIV/AIDS as one of the leading causes of
death from an infectious disease. Erythroderma, or generalized exfoliative dermatitis
is an uncommon but serious skin disorder which results in generalized scaling eruption
of the skin. It is usually drug induced, idiopathic, or secondary to underlying cutaneous
or systemic diseases. Theoretically, any drug may cause exfoliative dermatitis.
Isoniazid is established the first-line antitubercular drug and an essential component
of all antitubercular regimens. Erythroderma caused by isoniazid is an uncommon but
serious adverse drug reaction. We report here a case of a 54-year-old male patient who
presented with generalized redness and exfoliation of skin with itching after 6 weeks of
antitubercular treatment (ATT). ATT was stopped immediately, and antihistaminics
and steroids were started. The patient improved over a period of 2 weeks. On sequential
rechallenge, she developed similar lesions all over the body with isoniazid, hence
confirming the diagnosis of isoniazid-induced erythroderma.
Key words: Adverse drug reaction–Erythroderma–or generalized exfoliative
dermatitis–Isoniazid–Tuberculosis

Tuberculosis (TB) has existed for millennia and remains a major global health problem.
It causes ill-health in millions of people each year and in 2015 was one of the top
10 causes of death worldwide, ranking above HIV/AIDS as one of the leading causes of
death from an infectious disease. Erythroderma, or generalized exfoliative dermatitis
is an uncommon but serious skin disorder which results in generalized scaling eruption
of the skin. It is usually drug induced, idiopathic, or secondary to underlying cutaneous
or systemic diseases. Theoretically, any drug may cause exfoliative dermatitis.
Isoniazid is established the first-line antitubercular drug and an essential component
of all antitubercular regimens. Erythroderma caused by isoniazid is an uncommon but
serious adverse drug reaction. We report here a case of a 54-year-old male patient who
presented with generalized redness and exfoliation of skin with itching after 6 weeks of
antitubercular treatment (ATT). ATT was stopped immediately, and antihistaminics
and steroids were started. The patient improved over a period of 2 weeks. On sequential
rechallenge, she developed similar lesions all over the body with isoniazid, hence
confirming the diagnosis of isoniazid-induced erythroderma.
Key words: Adverse drug reaction–Erythroderma–or generalized exfoliative
dermatitis–Isoniazid–Tuberculosis